NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases.

Amino Acid Motifs Cell Line, Tumor HEK293 Cells HIV Integrase / chemistry HIV-1 / chemistry Humans Protein Domains
evolution human immunodeficiency virus integrase phylogenetic groups

Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
29 09 2020
Historique:
received: 26 05 2020
accepted: 17 07 2020
pubmed: 31 7 2020
medline: 16 12 2020
entrez: 31 7 2020
Statut: epublish

Résumé

Using coevolution network interference based on comparison of two phylogenetically distantly related isolates, one from the main group M and the other from the minor group O of HIV-1, we identify, in the C-terminal domain (CTD) of integrase, a new functional motif constituted by four noncontiguous amino acids (N

Identifiants

DOI: 10.1128/JVI.01035-20 PMID: 32727879 PMC: PMC7527040
pubmed: 32727879
pii: JVI.01035-20
doi: 10.1128/JVI.01035-20
pmc: PMC7527040
pii:
doi:

Substances chimiques

HIV Integrase EC 2.7.7.-

Banques de données

PDB
['https://doi.org/10.2210/pdb6T6I/pdb', 'https://doi.org/10.2210/pdb6T6E/pdb', 'https://doi.org/10.2210/pdb1C6V/pdb', 'https://doi.org/10.2210/pdb5LLJ/pdb', 'https://doi.org/10.2210/pdb1C0M/pdb', 'https://doi.org/10.2210/pdb5D7U/pdb', 'https://doi.org/10.2210/pdb2M9U/pdb', 'https://doi.org/10.2210/pdb4E7I/pdb', 'https://doi.org/10.2210/pdb1QMC/pdb', 'https://doi.org/10.2210/pdb6T6J/pdb']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 American Society for Microbiology.

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Auteurs

Marine Kanja (M)

Université de Strasbourg, CNRS, Architecture et Réactivité de l'ARN, Strasbourg, France.
Interdisciplinary Thematic Institute (ITI) InnoVec, Strasbourg, France.

Pierre Cappy (P)

Université de Strasbourg, CNRS, Architecture et Réactivité de l'ARN, Strasbourg, France.
Interdisciplinary Thematic Institute (ITI) InnoVec, Strasbourg, France.
ORCID: 0000-0001-8540-2196

Nicolas Levy (N)

Chromatin Stability and DNA Mobility, Department of Integrated Structural Biology, IGBMC, Strasbourg University, CNRS, INSERM, Illkirch, France.

Oyndamola Oladosu (O)

Chromatin Stability and DNA Mobility, Department of Integrated Structural Biology, IGBMC, Strasbourg University, CNRS, INSERM, Illkirch, France.

Sylvie Schmidt (S)

Molecular Immuno-Rheumatology Laboratory, UMR1109, FMTS, Université de Strasbourg, INSERM, Institut de Virologie, Strasbourg, France.

Paola Rossolillo (P)

Université de Strasbourg, CNRS, Architecture et Réactivité de l'ARN, Strasbourg, France.
Interdisciplinary Thematic Institute (ITI) InnoVec, Strasbourg, France.

Flore Winter (F)

Université de Strasbourg, CNRS, Architecture et Réactivité de l'ARN, Strasbourg, France.
Interdisciplinary Thematic Institute (ITI) InnoVec, Strasbourg, France.

Romain Gasser (R)

Université de Strasbourg, CNRS, Architecture et Réactivité de l'ARN, Strasbourg, France.
Interdisciplinary Thematic Institute (ITI) InnoVec, Strasbourg, France.

Christiane Moog (C)

Molecular Immuno-Rheumatology Laboratory, UMR1109, FMTS, Université de Strasbourg, INSERM, Institut de Virologie, Strasbourg, France.
ORCID: 0000-0002-0916-156X

Marc Ruff (M)

Chromatin Stability and DNA Mobility, Department of Integrated Structural Biology, IGBMC, Strasbourg University, CNRS, INSERM, Illkirch, France.

Matteo Negroni (M)

Université de Strasbourg, CNRS, Architecture et Réactivité de l'ARN, Strasbourg, France m.negroni@ibmc-cnrs.unistra.fr d.lener@ibmc-cnrs.unistra.fr.
Interdisciplinary Thematic Institute (ITI) InnoVec, Strasbourg, France.
ORCID: 0000-0003-3005-8871

Daniela Lener (D)

Université de Strasbourg, CNRS, Architecture et Réactivité de l'ARN, Strasbourg, France m.negroni@ibmc-cnrs.unistra.fr d.lener@ibmc-cnrs.unistra.fr.
Interdisciplinary Thematic Institute (ITI) InnoVec, Strasbourg, France.
ORCID: 0000-0001-8266-8810

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Motifs d'acides aminés › NKNK: a New Essential Motif in the C-Terminal...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › NKNK: a New Essential Motif in the C-Terminal...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › NKNK: a New Essential Motif in the C-Terminal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines nucléocapside › Protéines du core viral › Produits du gène pol › Produits du gène pol du virus de l'immunodéficience humaine › Intégrase du VIH › NKNK: a New Essential Motif in the C-Terminal...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › NKNK: a New Essential Motif in the C-Terminal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › NKNK: a New Essential Motif in the C-Terminal...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › NKNK: a New Essential Motif in the C-Terminal...