Offspring of obese mice display enhanced intake and sensitivity for palatable stimuli, with altered expression of taste signaling elements.
Adiposity
/ genetics
Animal Feed
Animals
Behavior, Animal
Diet, High-Fat
Feeding Behavior
Female
Lactation
Male
Mice
Mice, Inbred C57BL
Mice, Obese
Obesity
/ genetics
Phenotype
Pregnancy
Pregnancy, Animal
RNA, Messenger
/ metabolism
Receptors, G-Protein-Coupled
/ metabolism
Signal Transduction
Sucrose
/ analogs & derivatives
Taste
/ physiology
Taste Buds
Taste Perception
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 07 2020
29 07 2020
Historique:
received:
22
07
2019
accepted:
11
06
2020
entrez:
31
7
2020
pubmed:
31
7
2020
medline:
14
1
2021
Statut:
epublish
Résumé
Maternal body mass index and gestational weight gain predict future obesity status of the offspring. In studies of both rodents and non-human primates, maternal obesity also predicts a preference for palatable foods in the offspring. In this study, we used C57BL/6J mice to investigate whether an underlying cause for an increase in palatable food consumption in the offspring of obese mice was a change in taste function. Adult female mice were fed a normal chow (NC) or a high fat diet (HFD) for 5 weeks before mating, then also during the gestation (3 weeks) and lactation (3 weeks) periods, with offspring always maintained on a normal chow diet; thus the only experience offspring had with high fat food was via maternal exposure. Offspring exhibited similar weight, blood glucose levels and baseline water and chow intake in adulthood. Taste response was assessed after reaching maturity, using brief-access taste testing, with female offspring of obese dams showing an enhanced response to sucrose, and both sexes consuming more sucrose, sucralose and high fat diet if from obese mothers. Offspring also exhibited increased taste bud expression of mRNA for sweet receptor subunits T1R (Taste receptor type) 2 and 3, as well as other markers associated with taste signaling. Taste morphology in both groups appeared similar. Results indicate that obesity in the mother may lead to unhealthy feeding behavior in the offspring, correlating with altered expression of taste signaling elements, which likely drive increased avidity for palatable foods.
Identifiants
pubmed: 32728024
doi: 10.1038/s41598-020-68216-7
pii: 10.1038/s41598-020-68216-7
pmc: PMC7391633
doi:
Substances chimiques
RNA, Messenger
0
Receptors, G-Protein-Coupled
0
taste receptors, type 1
0
Sucrose
57-50-1
trichlorosucrose
96K6UQ3ZD4
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
12776Références
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