Humoral immune response to tick-borne encephalitis vaccination in allogeneic blood and marrow graft recipients.
Haematological cancer
Inactivated vaccines
Viral infection
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
2020
2020
Historique:
received:
09
04
2020
accepted:
03
07
2020
entrez:
31
7
2020
pubmed:
31
7
2020
medline:
31
7
2020
Statut:
epublish
Résumé
The aim of this prospective study was to characterize the humoral immune response to TBE vaccination after hematopoietic stem cell transplantation (HSCT). Nineteen adult patients 11-13 months after HSCT and 15 age-matched immunocompetent adults received up to three TBE vaccinations. Antibodies against TBE virus were measured by neutralization test (NT). As primary endpoint, the antibody response (NT titer of ≥10 and at least a twofold increase from baseline 4 weeks after second vaccination) was compared between patients and controls using Fisher exact test. Prior vaccination, 15 (79%) HSCT patients still had detectable neutralizing antibodies. At primary endpoint, the antibody response was significantly lower in patients than in controls (35% versus 93%;
Identifiants
pubmed: 32728481
doi: 10.1038/s41541-020-00215-1
pii: 215
pmc: PMC7381595
mid: EMS88042
doi:
Types de publication
Journal Article
Langues
eng
Pagination
67Subventions
Organisme : Austrian Science Fund FWF
ID : KLI 372
Pays : Austria
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsC.F. received a grant of the Austrian Science Fund (grant number KLI 372) that enabled to conduct the present study and partly supported employment of N.H. H.B. received a research grant from Pfizer (Project No. WI201689), who performed neutralization assays and supplied TBE vaccines free of cost. Pfizer had no role in the conceptualization, design of the study or the decision to publish. All other authors report no competing interests related to the present work.
Références
Br J Haematol. 1992 Oct;82(2):374-83
pubmed: 1419820
Neurol Neurochir Pol. 2011 Jul-Aug;45(4):402-6
pubmed: 22102003
Bone Marrow Transplant. 2015 Jul;50(7):978-83
pubmed: 25867652
Biol Blood Marrow Transplant. 2005 Dec;11(12):945-56
pubmed: 16338616
Blood. 2016 Jun 9;127(23):2824-32
pubmed: 27048212
Int J Med Microbiol. 2004 Apr;293 Suppl 37:139-44
pubmed: 15146996
Bone Marrow Transplant. 2009 Oct;44(8):521-6
pubmed: 19861986
Clin Infect Dis. 2014 Feb;58(3):e44-100
pubmed: 24311479
Vaccine. 2011 Nov 8;29(48):8769-70
pubmed: 21777636
J Med Virol. 1996 Jan;48(1):102-7
pubmed: 8825718
Bone Marrow Transplant. 2009 Oct;44(8):457-62
pubmed: 19861978
Blood. 1994 Jul 15;84(2):657-63
pubmed: 8025290
Clin Infect Dis. 2015 Aug 1;61(3):313-23
pubmed: 25870329
Bone Marrow Transplant. 2004 Oct;34(7):589-93
pubmed: 15300234
Vaccine. 2016 Jan 27;34(5):650-655
pubmed: 26718689
Infection. 2003 Jan;31(1):45-6
pubmed: 12590332
Eur J Intern Med. 2019 Apr;62:1-6
pubmed: 30678880
Vaccines (Basel). 2018 Oct 18;6(4):
pubmed: 30340377
Vaccine. 2009 Nov 23;27(50):7027-30
pubmed: 19786143
Vaccine. 2010 Apr 30;28(20):3511-5
pubmed: 20332047
Vaccine. 2009 Nov 23;27(50):7021-6
pubmed: 19789092
J Clin Virol. 2012 Jun;54(2):115-20
pubmed: 22421535
J Biol Stand. 1986 Apr;14(2):133-41
pubmed: 2428820
Ann Hematol. 2016 Sep;95(9):1435-55
pubmed: 27339055
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2020 May;63(5):588-644
pubmed: 32350583
Biol Blood Marrow Transplant. 2017 Oct;23(10):1614-1621
pubmed: 28624476
Br J Haematol. 2001 Dec;115(3):630-41
pubmed: 11736948
J Virol. 1997 Apr;71(4):2921-7
pubmed: 9060650
Bone Marrow Transplant. 2012 Jun;47(6):749-56
pubmed: 21643021
Vaccine. 2003 Apr 1;21 Suppl 1:S50-5
pubmed: 12628814
Clin Microbiol Infect. 2017 Jul;23(7):460-463
pubmed: 28143786
Vaccine. 2011 Apr 5;29(16):2825-33
pubmed: 21345379
Prog Clin Biol Res. 1987;244:449-60
pubmed: 2821549
Lancet Infect Dis. 2019 Jun;19(6):e200-e212
pubmed: 30744963
Vaccine. 1999 Feb 26;17(7-8):867-74
pubmed: 10067693
Vaccine. 2007 Oct 23;25(43):7559-67
pubmed: 17869389