Effect of sodium (
2-hydroxyglutarate
EGLN prolyl-4-hydroxylases
Hypoxia-inducible factors
Ischemia-reperfusion injury
Kidney
Succinic acid
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
01
2020
accepted:
08
06
2020
entrez:
31
7
2020
pubmed:
31
7
2020
medline:
31
7
2020
Statut:
epublish
Résumé
Ischemia-reperfusion (IR) injury is the main cause of delayed graft function in solid organ transplantation. Hypoxia-inducible factors (HIFs) control the expression of genes related to preconditioning against IR injury. During normoxia, HIF-α subunits are marked for degradation by the egg-laying defective nine homolog (EGLN) family of prolyl-4-hydroxylases. The inhibition of EGLN stabilizes HIFs and protects against IR injury. The aim of this study was to determine whether the EGLN inhibitors sodium ( ( ( None of the compounds were hepatotoxic at the tested doses. (
Sections du résumé
BACKGROUND
BACKGROUND
Ischemia-reperfusion (IR) injury is the main cause of delayed graft function in solid organ transplantation. Hypoxia-inducible factors (HIFs) control the expression of genes related to preconditioning against IR injury. During normoxia, HIF-α subunits are marked for degradation by the egg-laying defective nine homolog (EGLN) family of prolyl-4-hydroxylases. The inhibition of EGLN stabilizes HIFs and protects against IR injury. The aim of this study was to determine whether the EGLN inhibitors sodium (
METHODS
METHODS
(
RESULTS
RESULTS
(
CONCLUSION
CONCLUSIONS
None of the compounds were hepatotoxic at the tested doses. (
Identifiants
pubmed: 32728491
doi: 10.7717/peerj.9438
pii: 9438
pmc: PMC7357568
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e9438Informations de copyright
©2020 Cienfuegos-Pecina et al.
Déclaration de conflit d'intérêts
The authors declare there are no competing interests.
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