Cold sub-atmospheric and atmospheric pressure plasma for the treatment of Trichophyton rubrum onychomycosis: An in-vitro study.
Trichophyton rubrum
atmospheric pressure plasma cold plasma
onychomycosis treatment
sub-atmospheric pressure plasma
Journal
Dermatologic therapy
ISSN: 1529-8019
Titre abrégé: Dermatol Ther
Pays: United States
ID NLM: 9700070
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
11
07
2020
accepted:
25
07
2020
pubmed:
31
7
2020
medline:
15
5
2021
entrez:
31
7
2020
Statut:
ppublish
Résumé
Previous studies have suggested the applicability of cold atmospheric pressure plasma for the treatment of onychomycosis. Whether delivering cold plasma in sub-atmospheric pressure would be beneficial for this purpose is yet to be established. The current study aimed to evaluate efficacy of cold sub-atmospheric and atmospheric pressure plasma in Trichophyton rubrum growth inhibition. Bovine nails infected with T. rubrum were treated by a cold air plasma device, which enables utilizing plasma in sub-atmospheric pressures (Low = 100 millibar; High = 300 millibar) or atmospheric pressure. The infected foci were exposed to the plasma source directly or indirectly. Treatment with high sub-atmospheric pressure setting achieved T. rubrum growth reduction of 94.0% and 73.0%, for direct and indirect exposure to the plasma source, respectively (P < .001). Low sub-atmospheric pressure setting achieved similar T. rubrum growth reduction of 86.2% for direct exposure to the plasma source (P < .001), but only marginally significant 58.8% reduction rate for indirect exposure to the plasma source (P = .056). None statistically significant fungal growth reduction was attained with the use of atmospheric pressure setting. Cold plasma was shown to effectively inhibit T. rubrum nail growth, with sub-atmospheric pressure setting achieving better outcome than atmospheric pressure.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14084Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Lipner SR, Scher RK. Onychomycosis: clinical overview and diagnosis. J Am Acad Dermatol. 2019;80:835-851.
Milobratović D, Janković S, Vukičević J, Marinković J, Janković J, Railić Z. Quality of life in patients with toenail onychomycosis. Mycoses. 2013;56:543-551.
Shemer A. Update: medical treatment of onychomycosis. Dermatol Ther. 2012;25:582-593.
Kreijkamp-Kaspers S, Hawke K, Guo L, et al. Oral antifungal medication for toenail onychomycosis. Cochrane Database Syst Rev. 2017;7 (7):CD010031.
Foley K, Gupta AK, Versteeg S, et al. Topical and device-based treatments for fungal infections of the toenails. Cochrane Database Syst Rev. 2020;1 (1):CD012093.
Ma W, Si C, Kasyanju Carrero LM, et al. Laser treatment for onychomycosis: a systematic review and meta-analysis. Medicine (Baltimore). 2019;98:e17948.
Borges AC, Nishime TMC, de Moura Rovetta S, et al. Cold atmospheric pressure plasma jet reduces Trichophyton rubrum adherence and infection capacity. Mycopathologia. 2019;184:585-595.
Xiong Z, Roe J, Grammer TC, Graves DB. Plasma treatment of onychomycosis. Plasma Processes Polym. 2016;13:588-597.
Bulson JM, Liveris D, Derkatch I, et al. Non-thermal atmospheric plasma treatment of onychomycosis in an in vitro human nail model. Mycoses. 2020;63:225-232.
Lipner S, Friedman G, Scher R. Pilot study to evaluate a plasma device for the treatment of onychomycosis. Clin Exp Dermatol. 2017;42:295-298.
Shintani H, Sakudo A, Burke P, et al. Gas plasma sterilization of microorganisms and mechanisms of action. Exp Ther Med. 2010;1:731-738.
Scholtz V, Pazlarova J, Souskova H, Khun J, Julak J. Nonthermal plasma: a tool for decontamination and disinfection. Biotechnol Adv. 2015;33:1108-1119.
Patange A, Boehm D, Giltrap M, et al. Assessment of the disinfection capacity and eco-toxicological impact of atmospheric cold plasma for treatment of food industry effluents. Sci Total Environ. 2018;631:298-307.
Boyce JM. Modern technologies for improving cleaning and disinfection of environmental surfaces in hospitals. Antimicrob Resist Infect Control. 2016;5:10.
Handorf O, Weihe T, Bekeschus S, et al. Nonthermal plasma jet treatment negatively affects the viability and structure of Candida albicans SC5314 biofilms. Appl Environ Microbiol. 2018;84:e01163-18.
Heinlin J, Maisch T, Zimmermann JL, et al. Contact-free inactivation of Trichophyton rubrum and microsporum canis by cold atmospheric plasma treatment. Future Microbiol. 2013;8:1097-1106.
Maisch T, Shimizu T, Isbary G, et al. Contact-free inactivation of Candida albicans biofilms by cold atmospheric air plasma. Appl Environ Microbiol. 2012;78:4242-4247.
Lackmann J, Bandow JE. Inactivation of microbes and macromolecules by atmospheric-pressure plasma jets. Appl Microbiol Biotechnol. 2014;98:6205-6213.
Monti D, Saccomani L, Chetoni P, Burgalassi S, Tampucci S, Mailland F. Validation of bovine hoof slices as a model for infected human toenails: in vitro ciclopirox transungual permeation. Br J Dermatol. 2011;165:99-105.
Baraldi A, Jones S, Guesné S, et al. Human nail plate modifications induced by onychomycosis: implications for topical therapy. Pharm Res. 2015;32:1626-1633.
Johnson MJ, Go DB. Piezoelectric transformers for low-voltage generation of gas discharges and ionic winds in atmospheric air. J Appl Phys. 2015;118:243304.
Baran R, Faergemann J, Hay RJ. Superficial white onychomycosis: a syndrome with different fungal causes and paths of infection. J Am Acad Dermatol. 2007;57:879-882.
Pignata C, D'Angelo D, Basso D, et al. Low-temperature, low-pressure gas plasma application on Aspergillus brasiliensis, Escherichia coli and pistachios. J Appl Microbiol. 2014;116:1137-1148.
Ulbin-Figlewicz N, Jarmoluk A, Marycz K. Antimicrobial activity of low-pressure plasma treatment against selected foodborne bacteria and meat microbiota. Ann Microbiol. 2015;65:1537-1546.