Influence of Cell Membrane Wrapping on the Cell-Porous Silicon Nanoparticle Interactions.

biohybrids cancer cell membranes nanoparticle uptake nanoparticles protein corona

Journal

Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613

Informations de publication

Date de publication:
09 2020
Historique:
received: 01 04 2020
revised: 06 07 2020
pubmed: 31 7 2020
medline: 15 5 2021
entrez: 31 7 2020
Statut: ppublish

Résumé

Biohybrid nanosystems represent the cutting-edge research in biofunctionalization of micro- and nano-systems. Their physicochemical properties bring along advantages in the circulation time, camouflaging from the phagocytes, and novel antigens. This is partially a result of the qualitative differences in the protein corona, and the preferential targeting and uptake in homologous cells. However, the effect of the cell membrane on the cellular endocytosis mechanisms and time has not been fully evaluated yet. Here, the effect is assessed by quantitative flow cytometry analysis on the endocytosis of hydrophilic, negatively charged porous silicon nanoparticles and on their membrane-coated counterparts, in the presence of chemical inhibitors of different uptake pathways. Principal component analysis is used to analyze all the data and extrapolate patterns to highlight the cell-specific differences in the endocytosis mechanisms. Furthermore, the differences in the composition of static protein corona between naked and coated particles are investigated together with how these differences affect the interaction with human macrophages. Overall, the presence of the cell membrane only influences the speed and the entity of nanoparticles association with the cells, while there is no direct effect on the endocytosis pathways, composition of protein corona, or any reduction in macrophage-mediated uptake.

Identifiants

pubmed: 32729247
doi: 10.1002/adhm.202000529
doi:

Substances chimiques

Protein Corona 0
Silicon Z4152N8IUI

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2000529

Informations de copyright

© 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Références

R. H. Fang, A. V. Kroll, W. Gao, L. Zhang, Adv. Mater. 2018, 30, 1706759.
F. Fontana, M.-A. Shahbazi, D. Liu, H. Zhang, E. Mäkilä, J. Salonen, J. T. Hirvonen, H. A. Santos, Adv. Mater. 2017, 29, 1603239.
R. H. Fang, C.-M. J. Hu, B. T. Luk, W. Gao, J. A. Copp, Y. Tai, D. E. O'connor, L. Zhang, Nano Lett. 2014, 14, 2181.
R. Molinaro, C. Corbo, J. O. Martinez, F. Taraballi, M. Evangelopoulos, S. Minardi, I. K. Yazdi, P. Zhao, E. De Rosa, M. B. Sherman, A. De Vita, N. E. Toledano Furman, X. Wang, A. Parodi, E. Tasciotti, Nat. Mater. 2016, 15, 1037.
A. Parodi, N. Quattrocchi, A. L. Van De Ven, C. Chiappini, M. Evangelopoulos, J. O. Martinez, B. S. Brown, S. Z. Khaled, I. K. Yazdi, M. V. Enzo, L. Isenhart, M. Ferrari, E. Tasciotti, Nat. Nanotechnol. 2013, 8, 61.
C.-M. J. Hu, R. H. Fang, K.-C. Wang, B. T. Luk, S. Thamphiwatana, D. Dehaini, P. Nguyen, P. Angsantikul, C. H. Wen, A. V. Kroll, C. Carpenter, M. Ramesh, V. Qu, S. H. Patel, J. Zhu, W. Shi, F. M. Hofman, T. C. Chen, W. Gao, K. Zhang, S. Chien, L. Zhang, Nature 2015, 526, 118.
L. Rao, L.-L. Bu, B. Cai, J.-H. Xu, A. Li, W.-F. Zhang, Z.-J. Sun, S.-S. Guo, W. Liu, T.-H. Wang, X.-Z. Zhao, Adv. Mater. 2016, 28, 3460.
C. Corbo, R. Molinaro, F. Taraballi, N. E. Toledano Furman, K. A. Hartman, M. B. Sherman, E. De Rosa, D. K. Kirui, F. Salvatore, E. Tasciotti, ACS Nano 2017, 11, 3262.
D. Walczyk, F. B. Bombelli, M. P. Monopoli, I. Lynch, K. A. Dawson, J. Am. Chem. Soc. 2010, 132, 5761.
D. M. Beckwith, M. Cudic, Semin. Immunol. 2020, 47, 101389.
X. Liang, X. Ye, C. Wang, C. Xing, Q. Miao, Z. Xie, X. Chen, X. Zhang, H. Zhang, L. Mei, J. Controlled Release 2019, 296, 150.
F. Fontana, S. Albertini, A. Correia, M. Kemell, R. Lindgren, E. Mäkilä, J. Salonen, J. T. Hirvonen, F. Ferrari, H. A. Santos, Adv. Funct. Mater. 2018, 28, 1801355.
B. T. Luk, C.-M. Jack Hu, R. H. Fang, D. Dehaini, C. Carpenter, W. Gao, L. Zhang, Nanoscale 2014, 6, 2730.
R. Li, Y. He, S. Zhang, J. Qin, J. Wang, Acta Pharm. Sin. B 2018, 8, 14.
S. Behzadi, V. Serpooshan, W. Tao, M. A. Hamaly, M. Y. Alkawareek, E. C. Dreaden, D. Brown, A. M. Alkilany, O. C. Farokhzad, M. Mahmoudi, Chem. Soc. Rev. 2017, 46, 4218.
E. Polo, M. Collado, B. Pelaz, P. Del Pino, ACS Nano 2017, 11, 2397.
L. Zhang, Q. Feng, J. Wang, S. Zhang, B. Ding, Y. Wei, M. Dong, J.-Y. Ryu, T.-Y. Yoon, X. Shi, J. Sun, X. Jiang, ACS Nano 2015, 9, 9912.
R. Liu, W. Jiang, C. D. Walkey, W. C. W. Chan, Y. Cohen, Nanoscale 2015, 7, 9664.
N. Oh, J. H. Park, Int. J. Nanomed. 2014, 9 Suppl 1, 51
T. K. Kaiser, M. Khorenko, A. Moussavi, M. Engelke, S. Boretius, C. Feldmann, H. M. Reichardt, J. Controlled Release 2020, 319, 360.
S. Zhou, Y. Huang, Y. Chen, S. Liu, M. Xu, T. Jiang, Q. Song, G. Jiang, X. Gu, X. Gao, J. Chen, Biomaterials 2020, 235, 119795.
C. Corbo, R. Molinaro, A. Parodi, N. E. Toledano Furman, F. Salvatore, E. Tasciotti, Nanomedicine 2016, 11, 81.
V. Mirshafiee, R. Kim, S. Park, M. Mahmoudi, M. L. Kraft, Biomaterials 2016, 75, 295.
H. Wang, Y. Liu, R. He, D. Xu, J. Zang, N. Weeranoppanant, H. Dong, Y. Li, Biomater. Sci. 2020, 8, 552.
S. Sieber, P. Grossen, J. Bussmann, F. Campbell, A. Kros, D. Witzigmann, J. Huwyler, Adv. Drug Delivery Rev. 2019, 151, 152.
S. Sieber, P. Grossen, P. Uhl, P. Detampel, W. Mier, D. Witzigmann, J. Huwyler, Nanomed. Nanotechnol. 2019, 17, 82.
J. P. Martins, D. Liu, F. Fontana, M. P. A. Ferreira, A. Correia, S. Valentino, M. Kemell, K. Moslova, E. Mäkilä, J. Salonen, J. Hirvonen, B. Sarmento, H. A. Santos, ACS Appl. Mater. Interfaces 2018, 10, 44354.
J. P. Martins, R. D'auria, D. Liu, F. Fontana, M. P. A. Ferreira, A. Correia, M. Kemell, K. Moslova, E. Mäkilä, J. Salonen, L. Casettari, J. Hirvonen, B. Sarmento, H. A. Santos, Small 2018, 14, 1800462.
W. Li, Z. Liu, F. Fontana, Y. Ding, D. Liu, J. T. Hirvonen, H. A. Santos, Adv. Mater. 2018, 30, 1703740.
F. Araújo, N. Shrestha, M. J. Gomes, B. Herranz-Blanco, D. Liu, J. J. Hirvonen, P. L. Granja, H. A. Santos, B. Sarmento, Nanoscale 2016, 8, 10706.
M. P. A. Ferreira, S. Ranjan, A. M. R. Correia, E. M. Mäkilä, S. M. Kinnunen, H. Zhang, M.-A. Shahbazi, P. V. Almeida, J. J. Salonen, H. J. Ruskoaho, A. J. Airaksinen, J. T. Hirvonen, H. A. Santos, Biomaterials 2016, 94, 93.
A. Correia, M.-A. Shahbazi, E. Mäkilä, S. Almeida, J. Salonen, J. Hirvonen, H. A. Santos, ACS Appl. Mater. Interfaces 2015, 7, 23197.
J. Wolfram, H. Shen, M. Ferrari, J. Controlled Release 2015, 219, 406.
M.-A. Shahbazi, T. D. Fernández, E. M. Mäkilä, X. Le Guével, C. Mayorga, M. H. Kaasalainen, J. J. Salonen, J. T. Hirvonen, H. A. Santos, Biomaterials 2014, 35, 9224.
M. Fusciello, F. Fontana, S. Tähtinen, C. Capasso, S. Feola, B. Martins, J. Chiaro, K. Peltonen, L. Ylösmäki, E. Ylösmäki, F. Hamdan, O. K. Kari, J. Ndika, H. Alenius, A. Urtti, J. T. Hirvonen, H. A. Santos, V. Cerullo, Nat. Commun. 2019, 10, 5747.
L. Rao, G.-T. Yu, Q.-F. Meng, L.-L. Bu, R. Tian, L.-S. Lin, H. Deng, W. Yang, M. Zan, J. Ding, A. Li, H. Xiao, Z.-J. Sun, W. Liu, X. Chen, Adv. Funct. Mater. 2019, 29, 1905671.
L. Cai, Z. Gu, J. Zhong, D. Wen, G. Chen, L. He, J. Wu, Z. Gu, Drug Discovery Today 2018, 23, 1126.
Y. Jiang, S. Huo, T. Mizuhara, R. Das, Y.-W. Lee, S. Hou, D. F. Moyano, B. Duncan, X.-J. Liang, V. M. Rotello, ACS Nano 2015, 9, 9986.
Z. Luo, K. Cai, Y. Hu, B. Zhang, D. Xu, Adv. Healthcare Mater. 2012, 1, 321.
T. Dos Santos, J. Varela, I. Lynch, A. Salvati, K. A. Dawson, PLoS One 2011, 6, 24438.
D. A. Kuhn, D. Vanhecke, B. Michen, F. Blank, P. Gehr, A. Petri-Fink, B. Rothen-Rutishauser, Beilstein J. Nanotechnol. 2014, 5, 1625.
J. R. Heath, A. Ribas, P. S. Mischel, Nat. Rev. Drug Discovery 2016, 15, 204.
I. T. Jolliffe, J. Cadima, Philos. Trans. R. Soc., A 2016, 374, 20150202.
C. Meng, O. A. Zeleznik, G. G. Thallinger, B. Kuster, A. M. Gholami, A. C. Culhane, Briefings Bioinf. 2016, 17, 628.
J. Lever, M. Krzywinski, N. Altman, Nat. Methods 2017, 14, 641.
G. Caracciolo, O. C. Farokhzad, M. Mahmoudi, Trends Biotechnol. 2017, 35, 257.
H. Li, K. Jin, M. Luo, X. Wang, X. Zhu, X. Liu, T. Jiang, Q. Zhang, S. Wang, Z. Pang, Cells 2019, 8, 881.
D. Nie, Z. Dai, J. Li, Y. Yang, Z. Xi, J. Wang, W. Zhang, K. Qian, S. Guo, C. Zhu, R. Wang, Y. Li, M. Yu, X. Zhang, X. Shi, Y. Gan, Nano Lett. 2020, 20, 936.
A. Amici, G. Caracciolo, L. Digiacomo, V. Gambini, C. Marchini, M. Tilio, A. L. Capriotti, V. Colapicchioni, R. Matassa, G. Familiari, S. Palchetti, D. Pozzi, M. Mahmoudi, A. Laganà, RSC Adv. 2017, 7, 1137.
M. Sarparanta, L. M. Bimbo, J. Rytkönen, E. Mäkilä, T. J. Laaksonen, P. Laaksonen, M. Nyman, J. Salonen, M. B. Linder, J. Hirvonen, H. A. Santos, A. J. Airaksinen, Mol. Pharmaceutics 2012, 9, 654.
S. Keshavan, P. Calligari, L. Stella, L. Fusco, L. G. Delogu, B. Fadeel, Cell Death Dis. 2019, 10, 569.
A. Solorio-Rodríguez, V. Escamilla-Rivera, M. Uribe-Ramírez, A. Chagolla, R. Winkler, C. M. García-Cuellar, A. De Vizcaya-Ruiz, Nanoscale 2017, 9, 13651.
Q. Feng, X. Yang, Y. Hao, N. Wang, X. Feng, L. Hou, Z. Zhang, ACS Appl. Mater. Interfaces 2019, 11, 32729.
H. Sun, J. Su, Q. Meng, Q. Yin, L. Chen, W. Gu, P. Zhang, Z. Zhang, H. Yu, S. Wang, Y. Li, Adv. Mater. 2016, 28, 9581.

Auteurs

Flavia Fontana (F)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.

Hanna Lindstedt (H)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.

Alexandra Correia (A)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.

Jacopo Chiaro (J)

Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.

Otto K Kari (OK)

Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.

Joseph Ndika (J)

Human Microbiome Research, Faculty of Medicine, University of Helsinki, Helsinki, FI-00014, Finland.

Harri Alenius (H)

Human Microbiome Research, Faculty of Medicine, University of Helsinki, Helsinki, FI-00014, Finland.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SE-17177, Sweden.

Jonas Buck (J)

Department of Pharmaceutical Sciences, University of Basel, Basel, 4056, Switzerland.

Sandro Sieber (S)

Department of Pharmaceutical Sciences, University of Basel, Basel, 4056, Switzerland.

Ermei Mäkilä (E)

Laboratory of Industrial Physics, Department of Physics and Astronomy, University of Turku, Turku, FI-20014, Finland.

Jarno Salonen (J)

Laboratory of Industrial Physics, Department of Physics and Astronomy, University of Turku, Turku, FI-20014, Finland.

Arto Urtti (A)

Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.

Vincenzo Cerullo (V)

Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.
Translational Immunology Program (TRIMM), Digital Precision Cancer Flagship (iCAN), University of Helsinki, Helsinki, FI-00014, Finland.
Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, FI-00014, Finland.

Jouni T Hirvonen (JT)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.

Hélder A Santos (HA)

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.
Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, FI-00014, Finland.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH