Effects of Remote Ischemic Pre-Conditioning to Prevent Contrast-Induced Nephropathy after Intravenous Contrast Medium Injection: A Randomized Controlled Trial.
Acute Kidney Injury
/ diagnosis
Administration, Intravenous
Aged
Aged, 80 and over
Blood Pressure
Contrast Media
/ adverse effects
Creatinine
/ blood
Cystatin C
/ blood
Female
Humans
Ischemic Preconditioning
/ methods
Male
Prospective Studies
Risk Factors
Single-Blind Method
Tomography, X-Ray Computed
Acute kidney injury
Contrast media
Ischemic preconditioning
Nephropathy
Journal
Korean journal of radiology
ISSN: 2005-8330
Titre abrégé: Korean J Radiol
Pays: Korea (South)
ID NLM: 100956096
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
06
12
2019
revised:
22
02
2020
accepted:
31
03
2020
pubmed:
31
7
2020
medline:
16
2
2021
entrez:
31
7
2020
Statut:
ppublish
Résumé
We aimed to assess the effects of remote ischemic pre-conditioning (RIPC) on the incidence of contrast-induced nephropathy (CIN) after an intravenous (IV) or intra-arterial injection of contrast medium (CM) in patient and control groups. This prospective, randomized, single-blinded, controlled trial included 26 patients who were hospitalized for the evaluation of the feasibility of transcatheter aortic valve implantation and underwent investigations including contrast-enhanced computed tomography (CT), with Mehran risk scores greater than or equal to six. All the patients underwent four cycles of five minute-blood pressure cuff inflation followed by five minutes of total deflation. In the RIPC group (n = 13), the cuff was inflated to 50 mm Hg above the patient's systolic blood pressure (SBP); in the control group (n = 13), it was inflated to 10 mm Hg below the patient's SBP. The primary endpoint was the occurrence of CIN. Additionally, variation in the serum levels of cystatin C was assessed. One case of CIN was observed in the control group, whereas no cases were detected in the RIPC group ( The risk of CIN after an IV injection of CM is very low in patients with Mehran risk score greater than or equal to six and even in the patients who are unable to receive preventive hyperhydration. Hence, the Mehran risk score may not be an appropriate method for the estimation of the risk of CIN after IV CM injection.
Identifiants
pubmed: 32729273
pii: 21.e116
doi: 10.3348/kjr.2019.0916
pmc: PMC7462761
doi:
Substances chimiques
CST3 protein, human
0
Contrast Media
0
Cystatin C
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1230-1238Informations de copyright
Copyright © 2020 The Korean Society of Radiology.
Déclaration de conflit d'intérêts
The authors have no potential conflicts of interest to disclose.
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