Therapeutic effectiveness of thalidomide in a patient with treatment-resistant restless legs syndrome.
case report
restless legs syndrome
thalidomide
treatment
Journal
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
ISSN: 1550-9397
Titre abrégé: J Clin Sleep Med
Pays: United States
ID NLM: 101231977
Informations de publication
Date de publication:
15 10 2020
15 10 2020
Historique:
pubmed:
31
7
2020
medline:
24
6
2021
entrez:
31
7
2020
Statut:
ppublish
Résumé
Recent developments in the genetics of restless legs syndrome (RLS) revealed associations of disease risk with genetic loci containing the genes coding cereblon, the protein bound by thalidomide, and its endogenous substrate MEIS2, whose degradation is inhibited by the thalidomide-cereblon interaction. Therefore it was hypothesized that thalidomide may be a potential treatment option for RLS. Here we report on the therapeutic effect of thalidomide in a patient with otherwise treatment-resistant RLS who received 100 mg thalidomide off-label for 3 weeks. The female patient, severely affected by RLS before treatment, experienced significant amelioration of the symptoms, increased self-reported sleep quality, and better daytime functioning during thalidomide treatment. This therapeutic success warrants larger studies investigating the efficacy of drugs of the thalidomide class in RLS.
Identifiants
pubmed: 32729462
doi: 10.5664/jcsm.8696
pmc: PMC7954015
doi:
Substances chimiques
Thalidomide
4Z8R6ORS6L
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1815-1817Informations de copyright
© 2020 American Academy of Sleep Medicine.
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