Cost-utility analysis of normothermic liver perfusion with the OrganOx
H51
I00
OrganOx metra
cost-effectiveness analysis
liver transplantation
normothermic perfusion
organ preservation
Journal
Journal of medical economics
ISSN: 1941-837X
Titre abrégé: J Med Econ
Pays: England
ID NLM: 9892255
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
pubmed:
31
7
2020
medline:
24
8
2021
entrez:
31
7
2020
Statut:
ppublish
Résumé
Rising numbers of patients on the liver transplant waiting list has led to the utilization of organs from higher-risk donors that are more likely to be discarded and are prone to post-transplant complications. Storage and transportation of these livers at low temperatures can cause damage. OrganOx To evaluate the cost-utility of normothermic machine perfusion with OrganOx A de novo decision analytic model (a decision tree along with a Markov model), based on current treatment pathways, was developed to estimate the costs and outcomes. Results from a randomized clinical trial and national standard sources were used to inform the model. Costs were estimated from the National Health Service and Personal Social Services perspective. Deterministic and probabilistic sensitivity analyses (PSA) were conducted to explore uncertainty surrounding input parameters. Over a lifetime time horizon, liver transplantation with OrganOx Use of OrganOx
Sections du résumé
BACKGROUND
BACKGROUND
Rising numbers of patients on the liver transplant waiting list has led to the utilization of organs from higher-risk donors that are more likely to be discarded and are prone to post-transplant complications. Storage and transportation of these livers at low temperatures can cause damage. OrganOx
OBJECTIVE
OBJECTIVE
To evaluate the cost-utility of normothermic machine perfusion with OrganOx
METHODS
METHODS
A de novo decision analytic model (a decision tree along with a Markov model), based on current treatment pathways, was developed to estimate the costs and outcomes. Results from a randomized clinical trial and national standard sources were used to inform the model. Costs were estimated from the National Health Service and Personal Social Services perspective. Deterministic and probabilistic sensitivity analyses (PSA) were conducted to explore uncertainty surrounding input parameters.
RESULTS
RESULTS
Over a lifetime time horizon, liver transplantation with OrganOx
CONCLUSIONS
CONCLUSIONS
Use of OrganOx
Identifiants
pubmed: 32729749
doi: 10.1080/13696998.2020.1804391
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM