Multidrug Resistant Tuberculosis With Simultaneously Acquired Drug Resistance to Bedaquiline and Delamanid.
acquired drug resistance
bedaquiline
delamanid
tuberculosis
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213
Informations de publication
Date de publication:
16 12 2021
16 12 2021
Historique:
received:
09
06
2020
accepted:
25
07
2020
pubmed:
31
7
2020
medline:
15
3
2022
entrez:
31
7
2020
Statut:
ppublish
Résumé
This study is the first to report a clinical case of simultaneously acquired resistance to bedaquiline (BDQ) and delamanid (DLM). Whole genome sequencing revealed 2 nucleotide insertions (Rv0678 and fbiC) in the Mycobacterium tuberculosis isolate. The minimum inhibitory concentrations for BDQ and DLM were 0.25 µg/mL and >2.0 µg/mL, respectively.
Identifiants
pubmed: 32730621
pii: 5879015
doi: 10.1093/cid/ciaa1064
doi:
Substances chimiques
Antitubercular Agents
0
Diarylquinolines
0
Nitroimidazoles
0
OPC-67683
0
Oxazoles
0
bedaquiline
78846I289Y
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2329-2331Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP20fk01081727
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.