Recent advancement in the discovery and development of anti-epileptic biomolecules: An insight into structure activity relationship and Docking.
Anti-epileptic agents
Challenges and limitations
Convulsion
Docking
SAR
Journal
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982
Informations de publication
Date de publication:
01 Oct 2020
01 Oct 2020
Historique:
received:
03
06
2020
revised:
20
07
2020
accepted:
27
07
2020
pubmed:
31
7
2020
medline:
22
6
2021
entrez:
31
7
2020
Statut:
ppublish
Résumé
Although there have been many advancements in scientific research and development, the cause of epilepsy still remains an open challenge. In spite of high throughput research in the field of anti-epileptic drugs, efficacy void is still prevalent before the researchers. Researchers have persistently been exploring all the possibilities to curb undesirable side effects of the anti-epileptic drugs or looking for a more substantial approach to diminish or cure epilepsy. The drug development has shown a hope to medicinal chemists and researchers to carry further research by going through a substantial literature survey. This review article attempts to describe the recent developments in the anti-epileptic agents, pertaining to different molecular scaffolds considering their structure-activity relationship, docking studies and their mechanism of actions.
Identifiants
pubmed: 32730845
pii: S0928-0987(20)30283-9
doi: 10.1016/j.ejps.2020.105494
pii:
doi:
Substances chimiques
Anticonvulsants
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
105494Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.