Progesterone - Friend or foe?
Allopregnanolone
Emotion
Hormonal contraceptives
Postpartum depression
Premenstrual dysphoric disorder
Progesterone
Journal
Frontiers in neuroendocrinology
ISSN: 1095-6808
Titre abrégé: Front Neuroendocrinol
Pays: United States
ID NLM: 7513292
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
31
03
2020
revised:
05
07
2020
accepted:
24
07
2020
pubmed:
31
7
2020
medline:
22
5
2021
entrez:
31
7
2020
Statut:
ppublish
Résumé
Estradiol is the "prototypic" sex hormone of women. Yet, women have another sex hormone, which is often disregarded: Progesterone. The goal of this article is to provide a comprehensive review on progesterone, and its metabolite allopregnanolone, emphasizing three key areas: biological properties, main functions, and effects on mood in women. Recent years of intensive research on progesterone and allopregnanolone have paved the way for new treatment of postpartum depression. However, treatment for premenstrual syndrome and premenstrual dysphoric disorder as well as contraception that women can use without risking mental health problems are still needed. As far as progesterone is concerned, we might be dealing with a two-edged sword: while its metabolite allopregnanolone has been proven useful for treatment of PPD, it may trigger negative symptoms in women with PMS and PMDD. Overall, our current knowledge on the beneficial and harmful effects of progesterone is limited and further research is imperative.
Identifiants
pubmed: 32730861
pii: S0091-3022(20)30047-9
doi: 10.1016/j.yfrne.2020.100856
pii:
doi:
Substances chimiques
Progesterone
4G7DS2Q64Y
Pregnanolone
BXO86P3XXW
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100856Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.