Learning from BMPs and their biophysical extracellular matrix microenvironment for biomaterial design.
BMPs
Bioinspiration
Biomaterials
Extracellular matrix
Mechanotransduction
Journal
Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
02
05
2020
revised:
17
07
2020
accepted:
18
07
2020
pubmed:
31
7
2020
medline:
22
6
2021
entrez:
31
7
2020
Statut:
ppublish
Résumé
It is nowadays well-accepted that the extracellular matrix (ECM) is not a simple reservoir for growth factors but is an organization center of their biological activity. In this review, we focus on the ability of the ECM to regulate the biological activity of BMPs. In particular, we survey the role of the ECM components, notably the glycosaminoglycans and fibrillary ECM proteins, which can be promoters or repressors of the biological activities mediated by the BMPs. We examine how a process called mechano-transduction induced by the ECM can affect BMP signaling, including BMP internalization by the cells. We also focus on the spatio-temporal regulation of the BMPs, including their release from the ECM, which enables to modulate their spatial localization as well as their local concentration. We highlight how biomaterials can recapitulate some aspects of the BMPs/ECM interactions and help to answer fundamental questions to reveal previously unknown molecular mechanisms. Finally, the design of new biomaterials inspired by the ECM to better present BMPs is discussed, and their use for a more efficient bone regeneration in vivo is also highlighted.
Identifiants
pubmed: 32730925
pii: S8756-3282(20)30320-3
doi: 10.1016/j.bone.2020.115540
pmc: PMC7614069
mid: EMS159209
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Bone Morphogenetic Proteins
0
Extracellular Matrix Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
115540Subventions
Organisme : European Research Council
ID : 259370
Pays : International
Organisme : EPA
ID : EP-C-13-022
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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