Qualitative and quantitative analyses of quinones in multi-origin Rubia species by ultra-performance liquid chromatography-tandem mass spectrometry combined with chemometrics.
Analysis
Chemometrics
Multiple reaction monitor
Quinones
Rubia species
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
10 Sep 2020
10 Sep 2020
Historique:
received:
09
02
2020
revised:
06
07
2020
accepted:
08
07
2020
pubmed:
31
7
2020
medline:
22
6
2021
entrez:
31
7
2020
Statut:
ppublish
Résumé
Rubia species are one of the important multi-origin phytomedicines having both economical and medicinal values in many countries. Quinones are the predominant bioactive constituents of these species. Therefore, accurate analysis of these quinones is critical to quality control, clinical, and commercial applications of Rubia species. In this study, a sensitive and efficient ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (UPLC-QqQ-MS/MS) method in positive and negative multiple reaction monitor (+/-MRM) modes was firstly developed for the characterization of 45 quinones and the quantification of 24 quinones from Rubia plants. The chromatographic separation was achieved on a Waters ACQUITY UPLC® BEH C
Identifiants
pubmed: 32731129
pii: S0731-7085(20)31357-1
doi: 10.1016/j.jpba.2020.113471
pii:
doi:
Substances chimiques
Drugs, Chinese Herbal
0
Quinones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113471Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.