Inflammatory Cells in Diffuse Large B Cell Lymphoma.
DLBCL
NK cells
T cells
dendritic cells
macrophages
neutrophils
tumor cells
tumor microenvironment
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
28 Jul 2020
28 Jul 2020
Historique:
received:
10
07
2020
revised:
17
07
2020
accepted:
24
07
2020
entrez:
1
8
2020
pubmed:
1
8
2020
medline:
1
8
2020
Statut:
epublish
Résumé
Diffuse large B cell lymphoma (DLBCL), known as the most common non-Hodgkin lymphoma (NHL) subtype, is characterized by high clinical and biological heterogeneity. The tumor microenvironment (TME), in which the tumor cells reside, is crucial in the regulation of tumor initiation, progression, and metastasis, but it also has profound effects on therapeutic efficacy. The role of immune cells during DLBCL development is complex and involves reciprocal interactions between tumor cells, adaptive and innate immune cells, their soluble mediators and structural components present in the tumor microenvironment. Different immune cells are recruited into the tumor microenvironment and exert distinct effects on tumor progression and therapeutic outcomes. In this review, we focused on the role of macrophages, Neutrophils, T cells, natural killer cells and dendritic cells in the DLBCL microenvironment and their implication as target for DLBCL treatment. These new therapies, carried out by the induction of adaptive immunity through vaccination or passive of immunologic effectors delivery, enhance the ability of the immune system to react against the tumor antigens inducing the destruction of tumor cells.
Identifiants
pubmed: 32731512
pii: jcm9082418
doi: 10.3390/jcm9082418
pmc: PMC7463675
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Association against non- Hodgkin lymphomas
ID : "Il Sorriso di Antonio", Corato, Italy
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