[Low grade glioma with MYBL1 alteration: Case report of an uncommon pediatric neoplasm].
Gliome de bas grade avec altération de MYBL1 : observation d’une nouvelle entité tumorale pédiatrique.
Diffuse glioma
Epilepsy
Gliome diffus
Isomorphe
MYBL1
MYBL1: Isomorphic
Pediatric
Pédiatrie
Épilepsie
Journal
Annales de pathologie
ISSN: 0242-6498
Titre abrégé: Ann Pathol
Pays: France
ID NLM: 8106337
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
14
05
2020
revised:
19
06
2020
accepted:
07
07
2020
pubmed:
1
8
2020
medline:
16
10
2021
entrez:
1
8
2020
Statut:
ppublish
Résumé
Diffuse gliomas with MYB or MYBL1 alterations are rare tumours mostly affecting children or young adults with long-term epilepsy. This category of glioma includes two morphological subtypes. The angiocentric subtype is characterized by an angiocentric pattern of growth and a frequent MYB:QKI fusion. The isomorphic subtype corresponds to a highly differentiated astrocytic glioma with low cellularity, low proliferation and no specific microscopic features. The diagnosis is based on the imaging, demonstrating a supratentorial tumor, associated with the confirmation of a MYB or MYBL1 rearrangement. Here, we report the case of a 7-year-old child who presented a right frontal brain lesion corresponding to an isomorphic diffuse glioma with MYBL1 alteration.
Identifiants
pubmed: 32732147
pii: S0242-6498(20)30183-8
doi: 10.1016/j.annpat.2020.07.003
pii:
doi:
Substances chimiques
MYBL1 protein, human
0
Proto-Oncogene Proteins
0
Trans-Activators
0
Types de publication
Case Reports
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
129-133Informations de copyright
Copyright © 2020 Elsevier Masson SAS. All rights reserved.