Lysocardiolipin acyltransferase regulates NSCLC cell proliferation and migration by modulating mitochondrial dynamics.
1-Acylglycerol-3-Phosphate O-Acyltransferase
/ genetics
A549 Cells
Animals
Carcinoma, Non-Small-Cell Lung
/ enzymology
Cardiolipins
/ genetics
Cell Proliferation
Heterografts
Humans
Lung Neoplasms
/ enzymology
Mice
Mice, Nude
Mitochondria
/ genetics
Neoplasm Proteins
/ genetics
Neoplasm Transplantation
LYCAT
NSCLC
cardiolipin
cell cycle
cell migration
cell motility
cell proliferation
lysocardiolipin acyltransferase
non-small-cell lung cancer
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
18 09 2020
18 09 2020
Historique:
received:
15
01
2020
revised:
15
07
2020
pubmed:
1
8
2020
medline:
27
1
2021
entrez:
1
8
2020
Statut:
ppublish
Résumé
Lysocardiolipin acyltransferase (LYCAT), a cardiolipin (CL)-remodeling enzyme, is crucial for maintaining normal mitochondrial function and vascular development. Despite the well-characterized role for LYCAT in the regulation of mitochondrial dynamics, its involvement in lung cancer, if any, remains incompletely understood. In this study,
Identifiants
pubmed: 32732285
pii: S0021-9258(17)50052-6
doi: 10.1074/jbc.RA120.012680
pmc: PMC7504921
pii:
doi:
Substances chimiques
Cardiolipins
0
Neoplasm Proteins
0
1-Acylglycerol-3-Phosphate O-Acyltransferase
EC 2.3.1.51
LCLAT1 protein, human
EC 2.3.1.51
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13393-13406Subventions
Organisme : NCI NIH HHS
ID : R01 CA165065
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI145406
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA243142
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002003
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM113908
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL114453
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127342
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL060678
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL126609
Pays : United States
Informations de copyright
© 2020 Huang et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
Références
Biochim Biophys Acta. 2002 Dec 30;1585(2-3):97-107
pubmed: 12531542
Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E647-53
pubmed: 19106248
JCI Insight. 2019 Jul 23;5:
pubmed: 31335325
Blood. 2007 Nov 15;110(10):3601-9
pubmed: 17675553
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W169-75
pubmed: 17576678
Cell Metab. 2015 Feb 3;21(2):273-286
pubmed: 25600785
Prog Lipid Res. 2000 May;39(3):257-88
pubmed: 10799718
Science. 1929 Oct 18;70(1816):381-2
pubmed: 17756191
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96
pubmed: 18287387
Trends Cell Biol. 2018 Jan;28(1):67-76
pubmed: 28911913
J Biol Chem. 2004 Jul 23;279(30):31727-34
pubmed: 15152008
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Biochim Biophys Acta. 2009 Oct;1788(10):2003-14
pubmed: 19619503
Mol Cell Biochem. 2015 Dec;410(1-2):175-85
pubmed: 26314254
Biomed Res Int. 2015;2015:891707
pubmed: 26301254
J Lipid Res. 2008 Dec;49(12):2545-56
pubmed: 18703489
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Curr Med Chem. 2014;21(23):2702-14
pubmed: 24735357
Can J Biochem Physiol. 1959 Aug;37(8):911-7
pubmed: 13671378
Nucleic Acids Res. 2012 May;40(10):4288-97
pubmed: 22287627
Biochim Biophys Acta. 1998 Feb 5;1390(1):65-72
pubmed: 9487141
J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Jan 5;814(1):21-8
pubmed: 15607704
Apoptosis. 2016 Dec;21(12):1327-1335
pubmed: 27658785
Expert Opin Investig Drugs. 2014 May;23(5):675-92
pubmed: 24654596
PLoS Pathog. 2016 Aug 19;12(8):e1005829
pubmed: 27541004
J Biol Chem. 1957 May;226(1):497-509
pubmed: 13428781
Behav Brain Res. 2001 Nov 1;125(1-2):279-84
pubmed: 11682119
Essays Biochem. 2018 Jul 20;62(3):341-360
pubmed: 30030364
Cardiovasc Hematol Disord Drug Targets. 2014;14(2):98-106
pubmed: 24801725
FASEB J. 2012 May;26(5):2175-86
pubmed: 22321727
Cancer Res. 2016 Nov 15;76(22):6588-6597
pubmed: 27659048
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
Biochim Biophys Acta. 2013 Aug;1832(8):1194-206
pubmed: 23523468
Lung Cancer. 2010 Oct;70(1):37-42
pubmed: 20116128
J Biomed Res. 2010 Jan;24(1):6-15
pubmed: 23554606
Free Radic Biol Med. 2017 Nov;112:162-173
pubmed: 28751023
N Engl J Med. 2008 Sep 25;359(13):1367-80
pubmed: 18815398
Nature. 2015 Jan 22;517(7535):489-92
pubmed: 25363767
Am J Respir Crit Care Med. 2014 Jun 1;189(11):1402-15
pubmed: 24779708
Genome Biol. 2007;8(9):R183
pubmed: 17784955
Oncogene. 2013 Aug 22;32(34):4028-33
pubmed: 22945650