Precision-based exercise as a new therapeutic option for children and adolescents with haematological malignancies.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 07 2020
30 07 2020
Historique:
received:
29
01
2020
accepted:
03
07
2020
entrez:
1
8
2020
pubmed:
1
8
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Children and adolescents with haematological malignancies (PedHM) are characterized by a severe loss of exercise ability during cancer treatment, lasting throughout their lives once healed and impacting their social inclusion prospects. The investigation of the effect of a precision-based exercise program on the connections between systems of the body in PedHM patients is the new frontier in clinical exercise physiology. This study is aimed at evaluating the effects of 11 weeks (3 times weekly) of combined training (cardiorespiratory, resistance, balance and flexibility) on the exercise intolerance in PedHM patients. Two-hundred twenty-six PedHM patients were recruited (47% F). High or medium frequency participation (HAd and MAd) was considered when a participant joined; > 65% or between 30% and < 64% of training sessions, respectively. The "up and down stairs'' test (TUDS), "6 min walking" test (6MWT), the "5 Repetition Maximum strength" leg extension and arm lateral raise test (5RM-LE and 5RM-ALR), flexibility (stand and reach), and balance (stabilometry), were performed and evaluated before and after training. The TUDS, the 5RM-LE and 5RM-ALR, and the flexibility exercises showed an increase in HAd and MAd groups (P < 0.05), while the 6MWT and balance tests showed improvement only in HAd group (P < 0.0001). These results support the ever-growing theory that, in the case of the treatment of PedHM, 'exercise is medicine' and it has the potential to increase the patient's chances of social inclusion.
Identifiants
pubmed: 32733066
doi: 10.1038/s41598-020-69393-1
pii: 10.1038/s41598-020-69393-1
pmc: PMC7393502
doi:
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12892Références
AIRTUM Working Group; CCM; AIEOP Working Group. Italian cancer figures, report 2012: Cancer in children and adolescents. Epidemiol. Prev. 37, 1–225 (2013).
The SIOPE strategic plan. A European cancer plan for children and adolescents. J. Cancer Policy. 8, 17–32 (2016).
ISPAH International Society for Physical Activity and Health. The Bangkok declaration on physical activity for global health and sustainable development. Br. J. Sports. Med. 19, 1389–1391 (2017).
YildizKabak, V., Calders, P., Duger, T., van Mohammed, J. & Breda, E. Short and long-term impairments of cardiopulmonary fitness level in previous childhood cancer cases: A systematic review. Supp. Care Cancer. 27, 69–86 (2019).
WHO. Global Action Plan on Physical Activity 2018–2030: More Active People for a Healthier World. Copenhagen. https://www.who.int/ncds/prevention/physical-activity/global-action-plan-2018-2030/en/ .
WHO Regional Office for Europe. Physical Activity Strategy for the WHO European Region 2016–2025. Copenhagen (2016). https://www.euro.who.int/en/publications/abstracts/physical-activity-strategy-for-the-who-european-region-20162025 .
Bloemen, M. A. et al. Factors associated with physical activity in children and adolescents with a physical disability: A systematic review. Dev. Med. Child Neurol. 57, 137–148 (2015).
pubmed: 25403649
Strauser, D. et al. Career readiness in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study. J. Cancer Surviv. 9, 20–29 (2015).
pubmed: 25047713
Timilshina, N. et al. Long recovery of quality of life and physical function over three years in adult survivors of acute myeloid leukemia after intensive chemotherapy. Leukemia 33, 15–25 (2019).
pubmed: 29884902
Nagarajan, R. et al. Quality of life in pediatric acute myeloid leukemia: Report from the Children’s Oncology Group. Cancer Med. 9, 4454–4464 (2019).
van Brussel, M., Takken, T., van der Lucia, A., Net, J. & Helders, P. J. M. Is physical fitness decreased in survivors of childhood leukemia? A systematic review. Leukemia 19, 13–17 (2005).
pubmed: 15526028
Howden, E. J. et al. Standing up to the cardiometabolic consequences of hematological cancers. Blood Rev. 32, 349–360 (2018).
pubmed: 29496356
Jenney, M. E., Faragher, E. B., Jones, P. H. & Woodcock, A. Lung function and exercise capacity in survivors of childhood leukaemia. Med. Pediatr. Oncol. 24, 222–230 (1995).
pubmed: 7700166
Armstrong, G. T., Stovall, M. & Robison, L. L. Long-term effects of radiation exposure among adult survivors of childhood cancer: Results from the childhood cancer survivor study. Radiat. Res. 174, 840–850 (2010).
pubmed: 21128808
pmcid: 3080029
Inaba, H. et al. Pulmonary dysfunction in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem cell transplantation. Cancer 116, 2020–2030 (2010).
pubmed: 20186702
pmcid: 2919832
Huang, T. T. et al. Pulmonary outcomes in survivors of childhood cancer: A systematic review. Chest 140, 881–901 (2011).
pubmed: 21415131
pmcid: 3904488
Akyay, A., Olcay, L., Sezer, N. & Sonmez, C. A. Muscle strength, motor performance, cardiac and muscle biomarkers in detection of muscle side effects during and after acute lymphoblastic leukemia treatment in children. J. Pediatr. Hematol. Oncol. 36, 594–598 (2014).
pubmed: 25330012
Lanfranconi, F. et al. Near infrared spectroscopy (NIRS) as a new non-invasive tool to detect oxidative skeletal muscle impairment in children survived to acute lymphoblastic leukaemia. PLoS One 9, 6 (2014).
Marchese, V. G. et al. Relationships among severity of osteonecrosis, pain, range of motion, and functional mobility in children, adolescent, and young adults with acute lymphoblastic leukemia. Phys. Therapy. 88, 341–350 (2008).
Harila-Saari, A. H., Huuskonen, U. E. J., Tolonen, U., Vainionpää, L. K. & Lanning, B. M. Motor nervous pathway function is impaired after treatment of childhood acute lymphoblastic leukemia: A study with motor evoked potentials. Med. Pediatr. Oncol. 36, 345–351 (2001).
pubmed: 11241435
San Juan, A. F. et al. Functional capacity of children with leukemia. Int. J. Sports Med. 29, 163–167 (2008).
pubmed: 17879894
Järvelä, L. S. et al. Physical activity and fitness in adolescent and young adult long-term survivors of childhood acute lymphoblastic leukaemia. J. Cancer Surviv. 4, 339–345 (2010).
pubmed: 20552291
Ness, K. K. et al. Skeletal, neuromuscular and fitness impairments among children with newly diagnosed acute lymphoblastic leukemia. Leuk. Lymphoma. 56, 1004–1011 (2015).
pubmed: 25030039
Deisenroth, A. et al. Muscle strength and quality of life in patients with childhood cancer at early phase of primary treatment. Pediatr. Hematol. Oncol. 33, 393–407 (2016).
pubmed: 27690707
van den Hartman, A., Bos, C., Stijnen, T. & Pieters, R. Decrease in peripheral muscle strenght and ankle dorsiflexion as long-term side effects of treatment for childhood cancer. Pediatr. Blood Cancer. 50, 833–837 (2008).
pubmed: 17763466
Galea, V., Wright, M. J. & Barr, R. D. Measurement of balance in survivors of acute lymphoblastic leukemia in childhood. Gait Posture 19, 1–10 (2004).
pubmed: 14741298
Gotte, M. et al. MOON-test—determination of motor performance in the pediatric oncology. Klin. Padiatr. 225, 133–137 (2013).
pubmed: 23599231
Cox, C. L. et al. Promoting physical activity in childhood cancer survivors. Cancer 115, 642–654 (2009).
pubmed: 19117349
pmcid: 2653221
Winter, C. et al. Level of activity in children undergoing cancer treatment corinna. Pediatr. Blood Cancer. 53, 438–443 (2009).
pubmed: 19415742
Tan, S. Y. et al. Physical activity of pediatric patients with acute leukemia undergoing induction or consolidation chemotherapy. Leuk. Res. 37, 14–20 (2013).
pubmed: 23099236
Braam, K. I. et al. Physical exercise training interventions for children and young adults during and after treatment for childhood cancer. Cochrane Database Syst. Rev. 31, CD008796 (2016).
Morales, J. S. et al. Exercise interventions and cardiovascular health in childhood cancer: A meta-analysis. Scand. J. Med. Sci. Sports. https://doi.org/10.1111/sms.13545 (2019).
doi: 10.1111/sms.13545
pubmed: 31482597
Hogarty, A. Longitudinal evaluation of cardiopulmonary performance during exercise after bone marrow transplantation in children. J. Ped. 136, 311–317 (2000).
Marchese, V. G., Chiarello, L. A. & Lange, B. J. Effects of physical therapy intervention for children with acute lymphoblastic leukemia. Pediatr. Blood. Cancer 42, 127–133 (2004).
pubmed: 14752875
San Juan, A. F. et al. Effects of an intrahospital exercise program intervention for children with leukemia. Med. Sci. Sports Exerc. 39, 13–21 (2007).
pubmed: 17218878
Perondi, M. B. et al. Effects of a combined aerobic and strength training program in youth patients with acute lymphoblastic leukemia. J. Sport Sci. Med. 11, 387–392 (2012).
Fiuza-Luces, C. et al. Exercise intervention in pediatric patients with solid tumors: The physical activity in pediatric cancer trial. Med. Sci. Sports Exerc. 49, 223–230 (2017).
pubmed: 27631396
Chamorro-Vina, C. et al. Exercise during hematopoietic stem cell transplant hospitalization in children. Med. Sci. Sports Exerc. 42, 1045–1053 (2010).
pubmed: 19997035
Bogg, T. T., Broderick, C., Shaw, P., Cohn, R. & Naumann, F. L. Feasibility of an inpatient exercise intervention for children undergoing hematopoietic stem cell transplant. Pediatr. Transplant. 19, 925–931 (2015).
pubmed: 26518227
Senn-Malashonak, A. et al. Psychophysical effects of an exercise therapy during pediatric stem cell transplantation: A randomized controlled trial. Bone Marrow Transplant. 54, 1827–1835 (2019).
pubmed: 31089282
Ross, W. L. et al. Physical activity barriers, preferences, and beliefs in childhood cancer patients. Support. Care Cancer. 21, 77–84 (2018).
Fairman, C. M., Zourdos, M. C., Helms, E. R. & Focht, B. C. A scientific rationale to improve resistance training prescription in exercise oncology. Sports Med. 47, 1457–1465 (2017).
pubmed: 28074412
Sasso, J. P. et al. A framework for prescription in exercise-oncology research. J. Cachexia Sarcopenia Muscle 6, 115–124 (2015).
pubmed: 26136187
pmcid: 4458077
Karsenty, G. & Mera, P. Molecular bases of the crosstalk between bone and muscle. Bone 115, 43–49 (2018).
pubmed: 28428077
Kohrt, W. M., Bloomfield, S. A., Little, K. D., Nelson, M. E. & Yingling, V. R. American College of Sports Medicine Position Stand: Physical activity and bone health. Med. Sci. Sports Exerc. 36, 1985–1996 (2004).
pubmed: 15514517
Giangregorio, L. & Blimkie, C. J. Skeletal adaptations to alterations in weight-bearing activity: A comparison of models of disuse osteoporosis. Sports Med. 32, 459–476 (2002).
pubmed: 12015807
Kabak, V. Y., Duger, T. & Cetinkaya, D. U. Investigation of the effects of an exercise program on physical functions and activities of daily life in pediatric hematopoietic stem cell transplantation. Pediatr Blood Cancer. 63, 1643–1648 (2016).
Zaino, C. A., Marchese, V. G. & Westcott, S. L. Timed up and down stairs test: Preliminary reliability and validity of a new measure of functional. Pediatr. Phys. Ther. 16, 90–98 (2004).
pubmed: 17057533
Tanir, M. K. & Kuguoglu, S. Impact of exercise on lower activity levels in children with acute lymphoblastic leukemia: A randomized controlled trial from Turkey. Rehabil. Nurs. 38, 48–59 (2013).
pubmed: 23365005
Geiger, R. et al. Six-minute walk test in children and adolescents. J. Pediatr. 150, 395–399 (2007).
pubmed: 17382117
Porcelli, S. et al. Role of skeletal muscles impairment and brain oxygenation in limiting oxidative metabolism during exercise after bed rest. J. Appl. Physiol 109, 101–111 (2010).
pubmed: 20395541
Wilson, C. L. et al. Influence of fitness on health status among survivors of acute lymphoblastic leukemia. Pediatr. Blood Cancer. 65, e27286 (2018).
pubmed: 30058279
pmcid: 6150801
Haupt, R., Spinetta, J. J. & Ban, I. Long term survivors of childhood cancer: Cure and care. The ERICE statement. Eur. J. Cancer 43, 1778–1780 (2007).
pubmed: 17543517
Varni, J. W., Seid, M. & Rode, C. A. The PedsQL TM: Measurement model for the pediatric quality of life inventory. Med. Care. 37, 126–139 (1999).
pubmed: 10024117
Chandrasekaran, S. et al. Correlation between changes in visual analog scale and patient-reported outcome scores and patient satisfaction after hip arthroscopic surgery. Orthop. J. Sports Med. 13(9), 2325967117724772 (2017).