Absence of Plekhg5 Results in Myelin Infoldings Corresponding to an Impaired Schwann Cell Autophagy, and a Reduced T-Cell Infiltration Into Peripheral Nerves.
PLEKHG5
Schwann cells
autophagy
immune response
myelin
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
02
2020
accepted:
28
05
2020
entrez:
1
8
2020
pubmed:
1
8
2020
medline:
1
8
2020
Statut:
epublish
Résumé
Inflammation and dysregulation of the immune system are hallmarks of several neurodegenerative diseases. An activated immune response is considered to be the cause of myelin breakdown in demyelinating disorders. In the peripheral nervous system (PNS), myelin can be degraded in an autophagy-dependent manner directly by Schwann cells or by macrophages, which are modulated by T-lymphocytes. Here, we show that the NF-κB activator Pleckstrin homology containing family member 5 (Plekhg5) is involved in the regulation of both Schwann cell autophagy and recruitment of T-lymphocytes in peripheral nerves during motoneuron disease.
Identifiants
pubmed: 32733205
doi: 10.3389/fncel.2020.00185
pmc: PMC7358705
doi:
Types de publication
Journal Article
Langues
eng
Pagination
185Informations de copyright
Copyright © 2020 Lüningschrör, Slotta, Heimann, Briese, Weikert, Massih, Appenzeller, Sendtner, Kaltschmidt and Kaltschmidt.
Références
J Neurochem. 1982 Nov;39(5):1261-5
pubmed: 6181197
J Neurosci. 2000 Jan 15;20(2):729-35
pubmed: 10632602
Genes Dev. 2008 Jun 15;22(12):1647-61
pubmed: 18559480
J Neurochem. 2005 Feb;92(4):850-8
pubmed: 15686487
J Autoimmun. 1998 Aug;11(4):287-99
pubmed: 9776706
J Cell Biol. 2015 Jul 6;210(1):153-68
pubmed: 26150392
EMBO Mol Med. 2012 Jun;4(6):486-99
pubmed: 22488882
Acta Neuropathol. 2000 Sep;100(3):299-304
pubmed: 10965800
Oncogene. 2001 Nov 1;20(50):7307-17
pubmed: 11704860
Acta Neuropathol. 2015 Jan;129(1):97-113
pubmed: 25421425
Eur J Neurosci. 2007 Aug;26(4):953-64
pubmed: 17714189
BMC Genomics. 2008 Oct 16;9:488
pubmed: 18925949
Neurobiol Dis. 2010 Feb;37(2):483-90
pubmed: 19914379
Mol Neurobiol. 2015 Aug;52(1):216-25
pubmed: 25143238
Nucleic Acids Res. 2002 Jan 1;30(1):207-10
pubmed: 11752295
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Am J Hum Genet. 2007 Jul;81(1):67-76
pubmed: 17564964
Nat Commun. 2017 Oct 30;8(1):678
pubmed: 29084947
Cell Rep. 2020 Mar 10;30(10):3506-3519.e6
pubmed: 32160553
J Cell Biol. 2012 Nov 26;199(5):799-816
pubmed: 23166352
Mol Cell Neurosci. 2006 Apr;31(4):685-91
pubmed: 16458537
Hum Mol Genet. 2013 Oct 15;22(20):4224-32
pubmed: 23777631
Annu Rev Cell Dev Biol. 2014;30:503-33
pubmed: 25288117
Mol Pain. 2009 Dec 10;5:70
pubmed: 20003309
Neurobiol Aging. 2015 Apr;36(4):1764.e9-1764.e18
pubmed: 25681989
Dev Cell. 2014 Jan 13;28(1):7-17
pubmed: 24434136
Nucleic Acids Res. 2016 Feb 29;44(4):e33
pubmed: 26464439
Nat Neurosci. 2020 May;23(5):676-689
pubmed: 32284604
Neuromolecular Med. 2006;8(1-2):175-90
pubmed: 16775375
Autophagy. 2016;12(1):1-222
pubmed: 26799652
J Neurosci. 2006 Aug 2;26(31):8206-16
pubmed: 16885234
Autoimmun Rev. 2010 Feb;9(4):233-6
pubmed: 19683076
J Immunol. 1994 Sep 1;153(5):2052-63
pubmed: 8051410
Neurology. 1996 May;46(5):1318-24
pubmed: 8628474
Glia. 2008 Nov 1;56(14):1566-77
pubmed: 18803324
J Cell Biol. 2012 Dec 24;199(7):1103-15
pubmed: 23253477
Orphanet J Rare Dis. 2013 Jul 12;8:104
pubmed: 23844677
Cold Spring Harb Perspect Biol. 2013 Sep 01;5(9):
pubmed: 24003209
J Neurocytol. 1992 May;21(5):382-90
pubmed: 1607881
Curr Opin Cell Biol. 2004 Aug;16(4):400-6
pubmed: 15261672
J Cell Biol. 2001 Jan 22;152(2):301-8
pubmed: 11266447
J Neurocytol. 1995 Sep;24(9):667-79
pubmed: 7500122
Cell Rep. 2017 Sep 12;20(11):2719-2734
pubmed: 28903050
Hum Mol Genet. 2013 May 1;22(9):1755-70
pubmed: 23359569
J Cell Biol. 2004 Nov 22;167(4):711-21
pubmed: 15557122
Anat Rec. 1977 Jul;188(3):307-14
pubmed: 332010
Glia. 2008 Jun;56(8):836-43
pubmed: 18383340
Neuron. 2017 Sep 27;96(1):98-114.e7
pubmed: 28957681
Neuron. 2012 Feb 23;73(4):729-42
pubmed: 22365547
J Neuropathol Exp Neurol. 1997 Jul;56(7):811-21
pubmed: 9210878
J Biol Chem. 1997 Dec 5;272(49):31092-9
pubmed: 9388261