Tubuloglomerular Feedback in Renal Glucosuria: Mimicking Long-term SGLT-2 Inhibitor Therapy.
SGLT-2 Inhibitor
glomerular filtration rate
iohexol clearance
kidney protection
tubuloglomerular feedback
Journal
Kidney medicine
ISSN: 2590-0595
Titre abrégé: Kidney Med
Pays: United States
ID NLM: 101756300
Informations de publication
Date de publication:
Historique:
entrez:
1
8
2020
pubmed:
1
8
2020
medline:
1
8
2020
Statut:
epublish
Résumé
A patient with renal glucosuria due to a congenital knock-out of the sodium-glucose cotransporter 2 (SGLT-2) protein because of a compound heterozygous mutation in the SLC5A2 gene may provide a natural model mimicking the effects of long-term SGLT-2 inhibitor therapy, which has been shown to exert kidney-protective effects beyond its antidiabetic properties. One possible mechanism for the protective effects of SGLT-2 inhibitor therapy might be the activation of tubuloglomerular feedback by increased outflow of sodium, chloride, and glucose to distal parts of the nephron, including the macula densa. Subsequently, afferent arteriolar vasoconstriction is induced and blood flow, intraglomerular filtration pressure, and glomerular filtration rate (GFR) all decline. However, prolonged tubuloglomerular feedback activation could change the sensitivity of tubuloglomerular feedback and hence decrease the beneficial effects of SGLT-2 inhibition on kidney function. Tubuloglomerular feedback is mediated by the Na
Identifiants
pubmed: 32734228
doi: 10.1016/j.xkme.2019.09.006
pii: S2590-0595(19)30175-X
pmc: PMC7380363
doi:
Types de publication
Case Reports
Langues
eng
Pagination
76-79Informations de copyright
© 2019 Published by Elsevier Inc. on behalf of the National Kidney Foundation, Inc.
Références
J Am Soc Nephrol. 2009 Nov;20(11):2305-13
pubmed: 19833901
Lancet. 2019 Jan 5;393(10166):31-39
pubmed: 30424892
Br J Clin Pharmacol. 1984 Jul;18(1):65-74
pubmed: 6743491
Am J Kidney Dis. 2018 Oct;72(4):538-546
pubmed: 30031564
Am J Physiol Regul Integr Comp Physiol. 2012 Jan 1;302(1):R75-83
pubmed: 21940401
J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jul 24;839(1-2):124-9
pubmed: 16675312
Kidney Int. 2019 Aug;96(2):489-504
pubmed: 31142441
Pediatr Transplant. 2011 Nov;15(7):760-5
pubmed: 21883753
N Engl J Med. 2017 Aug 31;377(9):839-848
pubmed: 28854085