Estimated dietary pesticide exposure from plant-based foods using NMF-derived profiles in a large sample of French adults.
Dietary exposure
Epidemiology
Organic farming
Pesticides
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
29
12
2019
accepted:
21
07
2020
pubmed:
1
8
2020
medline:
24
6
2021
entrez:
1
8
2020
Statut:
ppublish
Résumé
This study, conducted in participants of the NutriNet-Santé cohort, aims to identify dietary pesticide exposure profiles (derived from Non-negative Matrix Factorization) from conventional and organic foods among a large sample of general population French adults. Organic and conventional dietary intakes were assessed using a self-administered semi-quantitative food frequency questionnaire. Exposure to 25 commonly used pesticides was evaluated using food contamination data from Chemisches und Veterinäruntersuchungsamt Stuttgart accounting for farming system (organic or conventional). Dietary pesticide exposure profiles were identified using Non-Negative Matrix factorization (NMF), especially adapted for non-negative data with excess zeros. The NMF scores were introduced in a hierarchical clustering process. Overall, the identified clusters (N = 34,193) seemed to be exposed to the same compounds with gradual intensity. Cluster 1 displayed the lowest energy intake and estimated dietary pesticide exposure, high organic food (OF) consumption (23.3%) and a higher proportion of male participants than other groups. Clusters 2 and 5 presented intermediate energy intake, lower OF consumption and intermediate estimated pesticide exposure. Cluster 3 showed high conventional fruits and vegetable (FV) intake, high estimated pesticide exposure, and fewer smokers. Cluster 4 estimated pesticide exposure varied more across compounds than for other clusters, with highest estimated exposures for acetamiprid, azadirachtin, cypermethrin, pyrethrins, spinosad. OF proportion in the diet was the highest (31.5%). Estimated dietary pesticide exposures appeared to vary across the clusters and to be related to OF proportion in the diet. Clinical Trial Registry: NCT03335644.
Identifiants
pubmed: 32734347
doi: 10.1007/s00394-020-02344-8
pii: 10.1007/s00394-020-02344-8
doi:
Substances chimiques
Pesticides
0
Banques de données
ClinicalTrials.gov
['NCT03335644']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1475-1488Références
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