Stochastic intracellular regulation can remove oscillations in a model of tissue growth.
extracellular regulation
intracellular regulation
random initial conditions
tissue growth
Journal
Mathematical medicine and biology : a journal of the IMA
ISSN: 1477-8602
Titre abrégé: Math Med Biol
Pays: England
ID NLM: 101182345
Informations de publication
Date de publication:
15 12 2020
15 12 2020
Historique:
received:
17
01
2019
revised:
28
03
2020
accepted:
19
06
2020
pubmed:
1
8
2020
medline:
27
8
2021
entrez:
1
8
2020
Statut:
ppublish
Résumé
The work is devoted to the analysis of cell population dynamics where cells make a choice between differentiation and apoptosis. This choice is based on the values of intracellular proteins whose concentrations are described by a system of ordinary differential equations with bistable dynamics. Intracellular regulation and cell fate are controlled by the extracellular regulation through the number of differentiated cells. It is shown that the total cell number necessarily oscillates if the initial condition in the intracellular regulation is fixed. These oscillations can be suppressed if the initial condition is a random variable with a sufficiently large variation. Thus, the result of the work suggests a possible answer to the question about the role of stochasticity in the intracellular regulation.
Identifiants
pubmed: 32735317
pii: 5879256
doi: 10.1093/imammb/dqaa009
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
551-568Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of the Institute of Mathematics and its Applications. All rights reserved.