Zinc protection of fertilized eggs is an ancient feature of sexual reproduction in animals.
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
14
10
2019
accepted:
10
07
2020
revised:
12
08
2020
pubmed:
1
8
2020
medline:
8
9
2020
entrez:
1
8
2020
Statut:
epublish
Résumé
One of the earliest and most prevalent barriers to successful reproduction is polyspermy, or fertilization of an egg by multiple sperm. To prevent these supernumerary fertilizations, eggs have evolved multiple mechanisms. It has recently been proposed that zinc released by mammalian eggs at fertilization may block additional sperm from entering. Here, we demonstrate that eggs from amphibia and teleost fish also release zinc. Using Xenopus laevis as a model, we document that zinc reversibly blocks fertilization. Finally, we demonstrate that extracellular zinc similarly disrupts early embryonic development in eggs from diverse phyla, including Cnidaria, Echinodermata, and Chordata. Our study reveals that a fundamental strategy protecting human eggs from fertilization by multiple sperm may have evolved more than 650 million years ago.
Identifiants
pubmed: 32735558
doi: 10.1371/journal.pbio.3000811
pii: PBIOLOGY-D-19-03005
pmc: PMC7423145
doi:
Substances chimiques
Zinc
J41CSQ7QDS
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e3000811Subventions
Organisme : NICHD NIH HHS
ID : T32 HD087194
Pays : United States
Organisme : NICHD NIH HHS
ID : R00 HD069410
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM125638
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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