Glycoconjugated Metal Complexes as Cancer Diagnostic and Therapeutic Agents.
Warburg effect
cancer imaging
cancer therapy
glycoconjugated complexes
glycolytic metabolism
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
08 01 2021
08 01 2021
Historique:
received:
27
06
2020
pubmed:
1
8
2020
medline:
18
9
2021
entrez:
1
8
2020
Statut:
ppublish
Résumé
The possibility of selectively delivering metal complexes to a defined cohort of cells on the basis of their metabolic features is a highly challenging goal, which may be extremely useful for a series of purposes, including diagnosis and therapy of pathological states, such as cancer. Tumor cells display augmented requests for carbohydrates and, in particular, for glucose in order to sustain their high proliferation rate, which causes an increased glycolytic process (Warburg effect). Since several metal complexes display diagnostic and/or therapeutic properties, their conjugation to carbohydrate portions often induce their preferential accumulation in cancer cells, similarly to what is observed with fluorodeoxyglucose (FDG). In this review we have considered the latest developments of glycoconjugates containing metal complexes in their structures. These compounds are classified as diagnostic or therapeutic agents and are further systematically discussed on the basis of the metal atom they contain. Several diagnostic techniques are possible with these probes, since, depending on the metal species included in their structures, they may be employed in nuclear medicine (PET, SPECT), magnetic resonance imaging, luminescence and phosphorescence. At the same time, the lack of selective cytotoxicity displayed by several metal-based chemotherapeutic agents, may also be solved by the conjugation of these agents to carbohydrate portions. Overall, data so far available reveal the great potential of this chemical class in the early detection and in the cure of severe neoplastic diseases, which still needs to be fully explored in the clinic.
Identifiants
pubmed: 32735702
doi: 10.1002/cmdc.202000456
doi:
Substances chimiques
Antineoplastic Agents
0
Carbohydrates
0
Coordination Complexes
0
Metals
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
30-64Informations de copyright
© 2020 Wiley-VCH GmbH.
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