Hepatitis B core antigen-based vaccine demonstrates cross-neutralization against heterologous North American Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-2) strains.

Animals Antibodies, Neutralizing / immunology Antibodies, Viral / immunology Epitopes / immunology Female Hepatitis B Core Antigens / immunology Hepatitis B Vaccines / administration & dosage Mice Mice, Inbred BALB C Porcine Reproductive and Respiratory Syndrome / prevention & control Swine Vaccines, Virus-Like Particle / administration & dosage
Epitope HBcAg Heterologous viral neutralization PRRSV VLP Vaccine

Journal

Journal of virological methods
ISSN: 1879-0984
Titre abrégé: J Virol Methods
Pays: Netherlands
ID NLM: 8005839

Informations de publication

Date de publication:
11 2020
Historique:
received: 30 04 2020
revised: 21 07 2020
accepted: 27 07 2020
pubmed: 1 8 2020
medline: 24 7 2021
entrez: 1 8 2020
Statut: ppublish

Résumé

The U.S. swine industry have been bearing the financial impact of Porcine Reproductive and Respiratory Syndrome (PRRS) for decades. Absent of a safe and efficacious vaccine to combat PRRS virus's genetic heterogeneity, it remains a costly disease on pig farms across the country. We have developed virus-like-particle (VLP) based vaccines that incorporate 4 PRRSV epitopes in the hepatitis B core antigen (HBcAg) backbone. Administration of the vaccines in female BALB/C mice resulted in extremely significant PRRSV epitope specific antibody response. One vaccine candidate GP3-4 was able to mount a significant viral neutralizing response against both parental PRRSV strain VR2385 and heterologous PRRSV strain NADC20, showing a promising potential for cross-protection against PRRSV.

Identifiants

DOI: 10.1016/j.jviromet.2020.113945 PMID: 32735804
pubmed: 32735804
pii: S0166-0934(20)30197-X
doi: 10.1016/j.jviromet.2020.113945
pii:
doi:

Substances chimiques

Antibodies, Neutralizing 0
Antibodies, Viral 0
Epitopes 0
Hepatitis B Core Antigens 0
Hepatitis B Vaccines 0
Vaccines, Virus-Like Particle 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113945

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Yi Lu (Y)

Department of Biological Systems Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Electronic address: lewislu@vt.edu.

Frank Gillam (F)

Department of Biological Systems Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Electronic address: fbgillam@vt.edu.

Qian M Cao (QM)

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Electronic address: qiancao@vt.edu.

Amy Rizzo (A)

University Veterinarian & Animal Resources, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Electronic address: amyrizzo@vt.edu.

X J Meng (XJ)

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Electronic address: xjmeng@vt.edu.

Chenming Zhang (C)

Department of Biological Systems Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Electronic address: cmzhang@vt.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Hepatitis B core antigen-based vaccine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Hepatitis B core antigen-based vaccine...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Hepatitis B core antigen-based vaccine...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Hepatitis B core antigen-based vaccine...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes viraux › Antigènes d'hépatite virale › Antigènes de l'hépatite virale B › Antigènes de la nucléocapside du virus de l'hépatite virale B › Hepatitis B core antigen-based vaccine...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins contre les hépatites virales › Vaccins anti-hépatite B › Hepatitis B core antigen-based vaccine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Hepatitis B core antigen-based vaccine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Hepatitis B core antigen-based vaccine...
questionsmedicales.fr › Maladies de l'animal › Maladies des porcs › Syndrome dysgénésique et respiratoire porcin › Hepatitis B core antigen-based vaccine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › Hepatitis B core antigen-based vaccine...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Vaccins synthétiques › Vaccins à pseudo-particules virales › Hepatitis B core antigen-based vaccine...