Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans.

Animals Antigens, CD1 / metabolism Antigens, CD34 / metabolism Cell Line Cell Lineage / immunology Dendritic Cells / cytology Glycoproteins / metabolism Hematopoiesis / physiology Hematopoietic Stem Cells / cytology Humans Interferon Regulatory Factors / metabolism Interleukin-3 Receptor alpha Subunit / metabolism Lipopolysaccharide Receptors / metabolism Mice Receptors, Immunologic / metabolism
CyTOF IRF8 dendritic cell hematopoiesis immunity primary immunodeficiency single-cell RNA sequencing transcription factor

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
18 08 2020
Historique:
received: 26 03 2019
revised: 27 12 2019
accepted: 02 07 2020
pubmed: 1 8 2020
medline: 14 4 2021
entrez: 1 8 2020
Statut: ppublish

Résumé

The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets, including plasmacytoid DCs (pDCs) and the classical DC lineages cDC1 and cDC2. In humans, cDC2-related subsets have been described including AXL

Identifiants

DOI: 10.1016/j.immuni.2020.07.003 PMID: 32735845 PMC: PMC7447982
pubmed: 32735845
pii: S1074-7613(20)30283-1
doi: 10.1016/j.immuni.2020.07.003
pmc: PMC7447982
pii:
doi:

Substances chimiques

Antigens, CD1 0
Antigens, CD34 0
BTLA protein, human 0
CD14 protein, human 0
CD1C protein, human 0
Glycoproteins 0
IL3RA protein, human 0
Interferon Regulatory Factors 0
Interleukin-3 Receptor alpha Subunit 0
Lipopolysaccharide Receptors 0
Receptors, Immunologic 0
interferon regulatory factor-8 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

353-370.e8

Subventions

Organisme : Wellcome Trust
ID : 101155/Z/13/Z
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C30484/A21025
Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

Références

J Exp Med. 2015 Mar 9;212(3):385-99
pubmed: 25687283
Science. 2017 Apr 21;356(6335):
pubmed: 28428369
N Engl J Med. 2011 Jul 14;365(2):127-38
pubmed: 21524210
Immunol Cell Biol. 2016 May;94(5):447-57
pubmed: 26791160
Nat Immunol. 2018 Sep;19(9):973-985
pubmed: 30127434
Science. 1994 Aug 19;265(5175):1098-101
pubmed: 8066449
Nat Immunol. 2015 Jul;16(7):708-17
pubmed: 26054719
Nat Cell Biol. 2018 Jul;20(7):836-846
pubmed: 29915358
Genes Dev. 2004 Nov 15;18(22):2747-63
pubmed: 15545632
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
BMC Genomics. 2018 Jun 19;19(1):477
pubmed: 29914354
Bioinformatics. 2016 Apr 15;32(8):1241-3
pubmed: 26668002
J Allergy Clin Immunol. 2018 Jun;141(6):2234-2248
pubmed: 29128673
Bioinformatics. 2015 Sep 15;31(18):2989-98
pubmed: 26002886
Nat Immunol. 2015 Jul;16(7):718-28
pubmed: 26054720
Blood. 2014 May 8;123(19):2968-77
pubmed: 24677539
Nat Protoc. 2014 Jan;9(1):171-81
pubmed: 24385147
J Immunol. 2009 Jun 1;182(11):6815-23
pubmed: 19454677
Nat Commun. 2019 Jun 3;10(1):2395
pubmed: 31160568
Science. 2017 Jun 9;356(6342):
pubmed: 28473638
Cell. 2015 May 21;161(5):1202-1214
pubmed: 26000488
Blood. 2008 Feb 15;111(4):1942-5
pubmed: 18055870
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Nat Methods. 2017 May;14(5):483-486
pubmed: 28346451
Nat Commun. 2014 Sep 19;5:4978
pubmed: 25236377
Nat Immunol. 2017 Aug;18(8):877-888
pubmed: 28650480
PLoS One. 2016 Jun 16;11(6):e0157387
pubmed: 27311059
Nature. 2018 Jan 24;553(7689):418-426
pubmed: 29364285
Nat Cell Biol. 2017 Apr;19(4):271-281
pubmed: 28319093
Blood. 2014 Sep 18;124(12):1894-904
pubmed: 25122610
Annu Rev Immunol. 2016 May 20;34:93-119
pubmed: 26735697
Nature. 2013 Apr 11;496(7444):229-32
pubmed: 23552896
Immunity. 2016 Sep 20;45(3):626-640
pubmed: 27637148
Immunity. 2017 Dec 19;47(6):1037-1050.e6
pubmed: 29221729
Cell Rep. 2018 Jun 19;23(12):3658-3672.e6
pubmed: 29925006
Nat Commun. 2018 Mar 27;9(1):1239
pubmed: 29588478
Blood. 2014 Feb 6;123(6):863-74
pubmed: 24345756
Immunity. 2020 Aug 18;53(2):335-352.e8
pubmed: 32610077
Cell. 2015 Dec 17;163(7):1663-77
pubmed: 26627738
JCI Insight. 2017 Sep 21;2(18):
pubmed: 28931765
Bioinformatics. 2017 Apr 15;33(8):1179-1186
pubmed: 28088763
Curr Protoc Bioinformatics. 2015 Sep 03;51:11.14.1-11.14.19
pubmed: 26334920
Science. 2016 Jan 8;351(6269):aab2116
pubmed: 26541609
Cell. 2008 Oct 3;135(1):37-48
pubmed: 18854153
Immunity. 2017 Mar 21;46(3):504-515
pubmed: 28329707
Immunity. 2016 Sep 20;45(3):669-684
pubmed: 27637149
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
J Immunol. 2017 Feb 15;198(4):1553-1564
pubmed: 28087664
Nat Biotechnol. 2014 Sep;32(9):896-902
pubmed: 25150836
Immunology. 2018 May;154(1):3-20
pubmed: 29313948
BMC Genomics. 2015 Oct 19;16:814
pubmed: 26481321
Nat Immunol. 2017 Jul;18(7):813-823
pubmed: 28530713
Bioinformatics. 2005 Aug 15;21(16):3439-40
pubmed: 16082012
Blood. 2012 Mar 1;119(9):2003-12
pubmed: 22238324
Cell Rep. 2017 Jul 18;20(3):529-537
pubmed: 28723558

Auteurs

Urszula Cytlak (U)

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Anastasia Resteu (A)

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Sarah Pagan (S)

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Kile Green (K)

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Paul Milne (P)

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Sheetal Maisuria (S)

Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds LS9 7TF, UK.

David McDonald (D)

Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Gillian Hulme (G)

Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Andrew Filby (A)

Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Benjamin Carpenter (B)

Oxford Genomics Centre, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.

Rachel Queen (R)

Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Sophie Hambleton (S)

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK.

Rosie Hague (R)

Department of Paediatric Immunology and Infectious Diseases, Royal Hospital for Children, Glasgow G51 4TF, UK.

Hana Lango Allen (H)

Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0SP, UK; NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge CB2 0SP, UK.

James E D Thaventhiran (JED)

MRC Toxicology Unit, School of Biological Sciences, University of Cambridge, Cambridge CB2 1QR, UK.

Gina Doody (G)

Leeds Institute of Medical Research, University of Leeds, Leeds LS9 7TF, UK.

Matthew Collin (M)

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Northern Centre for Cancer Care, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK.

Venetia Bigley (V)

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; Northern Centre for Cancer Care, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK. Electronic address: venetia.bigley@ncl.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes CD1 › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › Antigènes CD34 › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de régulation d'interféron › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Sous-unité alpha du récepteur à l'interleukine-3 › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des myélomonocytes › Antigènes CD14 › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Differential IRF8 Transcription Factor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Differential IRF8 Transcription Factor...