Genetic liability to major depression and risk of childhood asthma.
Asthma
Cohort study
Genetic liability
Major depression
Polygenic risk score
Population-based
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
06
05
2020
revised:
08
07
2020
accepted:
22
07
2020
pubmed:
1
8
2020
medline:
28
4
2021
entrez:
1
8
2020
Statut:
ppublish
Résumé
Major depression and asthma frequently co-occur, suggesting shared genetic vulnerability between these two disorders. We aimed to determine whether a higher genetic liability to major depression was associated with increased childhood asthma risk, and if so, whether such an association differed by sex of the child. We conducted a population-based cohort study comprising 16,687 singletons born between 1991 and 2005 in Denmark. We calculated the polygenic risk score (PRS) for major depression as a measure of genetic liability based on the summary statistics from the Major Depressive Disorder Psychiatric Genomics Consortium collaboration. The outcome was incident asthma from age 5 to 15 years, identified from the Danish National Patient Registry and the Danish National Prescription Registry. Stratified Cox regression was used to analyze the data. Greater genetic liability to major depression was associated with an increased asthma risk with a hazard ratio (HR) of 1.06 (95% CI: 1.01-1.10) per standard deviation increase in PRS. Children in the highest major depression PRS quartile had a HR for asthma of 1.20 (95% CI: 1.06-1.36), compared with children in the lowest quartile. However, major depression PRS explained only 0.03% of asthma variance (Pseudo-R Our results suggest a shared genetic contribution to major depression and childhood asthma, and there is no evidence of a sex-specific difference in the association.
Identifiants
pubmed: 32735934
pii: S0889-1591(20)30850-3
doi: 10.1016/j.bbi.2020.07.030
pmc: PMC8817239
mid: NIHMS1618304
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
433-439Subventions
Organisme : NIMH NIH HHS
ID : R01 MH122869
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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