Biocompatible Fe-Hematoporphyrin coordination nanoplatforms with efficient sonodynamic-chemo effects on deep-seated tumors.

Animals Cell Line, Tumor Doxorubicin Ferric Compounds Hematoporphyrins Mice Neoplasms / therapy Tumor Microenvironment Ultrasonic Therapy
Deep-seated tumor Drug delivery Hematoporphyrin Metal-organic coordination Sonodynamic effect

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
10 2020
Historique:
received: 05 03 2020
revised: 12 07 2020
accepted: 14 07 2020
pubmed: 1 8 2020
medline: 15 5 2021
entrez: 1 8 2020
Statut: ppublish

Résumé

Sonodynamic therapy (SDT) utilizing semiconductors or organic sonosensitizers has attracted increasing attention as a noninvasive treatment for deep-seated tumors, but its practical applications are still limited due to unsatisfactory therapeutical effects. To address the issue, we reported a metal-organic nanosonosensitizer by assembling clinical drug hematoporphyrin monomethyl ether (HMME) with Fe(III) ions through covalently coordination. The Fe-HMME coordination particles (FeCPs) had the average size of ~70 nm, and they were surface-modified with phospholipids to confer high hydrophilicity and stability. Upon ultrasound irradiation, they efficiently produced

Identifiants

DOI: 10.1016/j.biomaterials.2020.120239 PMID: 32736261
pubmed: 32736261
pii: S0142-9612(20)30485-3
doi: 10.1016/j.biomaterials.2020.120239
pii:
doi:

Substances chimiques

Ferric Compounds 0
Hematoporphyrins 0
Doxorubicin 80168379AG

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

120239

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Hao Xu (H)

Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China; College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China.

Nuo Yu (N)

College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China.

Jiulong Zhang (J)

Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201620, China.

Zhaojie Wang (Z)

College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China.

Peng Geng (P)

College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China.

Mei Wen (M)

College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China.

Maoquan Li (M)

Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.

Haijun Zhang (H)

Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China; National United Engineering Laboratory for Biomedical Material Modification, Branden Biomedical Park, Qihe Advanced Science & High Technology Development Zone, Qihe, Shandong, 251100, China.

Zhigang Chen (Z)

Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China; College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China. Electronic address: zgchen@dhu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Biocompatible Fe-Hematoporphyrin coordination...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Biocompatible Fe-Hematoporphyrin coordination...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › Biocompatible Fe-Hematoporphyrin coordination...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du fer › Composés du fer III › Biocompatible Fe-Hematoporphyrin coordination...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Hématoporphyrines › Biocompatible Fe-Hematoporphyrin coordination...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Biocompatible Fe-Hematoporphyrin coordination...
questionsmedicales.fr › Tumeurs › Biocompatible Fe-Hematoporphyrin coordination...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Biocompatible Fe-Hematoporphyrin coordination...
questionsmedicales.fr › Thérapeutique › Hyperthermie provoquée › Diathermie › Ultrasonothérapie › Biocompatible Fe-Hematoporphyrin coordination...