Association of the
gene polymorphism
pulmonary fibrosis
rheumatoid arthritis
Journal
Annals of the rheumatic diseases
ISSN: 1468-2060
Titre abrégé: Ann Rheum Dis
Pays: England
ID NLM: 0372355
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
04
03
2020
revised:
22
06
2020
accepted:
25
06
2020
pubmed:
2
8
2020
medline:
24
11
2020
entrez:
2
8
2020
Statut:
ppublish
Résumé
The genetic background of rheumatoid arthritis-interstitial lung disease (RA-ILD) has been evaluated in Europeans, but little knowledge has been obtained in non-Europeans. This study aimed to elucidate genome-wide risk of RA-ILD in non-Europeans. We performed an initial genome-wide association study (GWAS) of RA-ILD in the Japanese population. By conducting the meta-analysis of the three GWAS datasets of the RA cohorts and biobank of Japanese, our study included 358 RA-ILD cases and 4550 RA subjects without ILD. We then conducted the stratified analysis of the effect of the GWAS risk allele in each CT image pattern. We identified one novel RA-ILD risk locus at 7p21 that satisfied the genome-wide significance threshold (rs12702634 at We revealed one novel genetic association with RA-ILD in Japanese. The RA-ILD risk of the identified variant at
Identifiants
pubmed: 32737115
pii: annrheumdis-2020-217256
doi: 10.1136/annrheumdis-2020-217256
pmc: PMC7509520
doi:
Substances chimiques
DNA-Binding Proteins
0
RNA, Antisense
0
RPA3 protein, human
0
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1305-1309Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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