Circulating Metabolites and Lipids Are Associated to Diabetic Retinopathy in Individuals With Type 1 Diabetes.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
27
01
2020
accepted:
29
07
2020
pubmed:
2
8
2020
medline:
26
1
2021
entrez:
2
8
2020
Statut:
ppublish
Résumé
Omics-based methods may provide new markers associated to diabetic retinopathy (DR). We investigated a wide omics panel of metabolites and lipids related to DR in type 1 diabetes. Metabolomic analyses were performed using two-dimensional gas chromatography with time-of-flight mass spectrometry and lipidomic analyses using an ultra-high-performance liquid chromatography quadruple time-of-flight mass spectrometry method in 648 individuals with type 1 diabetes. Subjects were subdivided into no DR, mild nonproliferative DR (NPDR), moderate NPDR, proliferative DR, and proliferative DR with fibrosis. End points were any progression of DR, onset of DR, and progression from mild to severe DR tracked from standard ambulatory care and investigated using Cox models. The cohort consisted of 648 participants aged a mean of 54.4 ± 12.8 years, 55.5% were men, and follow-up was 5.1-5.5 years. Cross-sectionally, 2,4-dihydroxybutyric acid (DHBA), 3,4-DHBA, ribonic acid, ribitol, and the triglycerides 50:1 and 50:2 significantly correlated (
Identifiants
pubmed: 32737117
pii: db20-0104
doi: 10.2337/db20-0104
pmc: PMC7506826
doi:
Substances chimiques
Triglycerides
0
Banques de données
figshare
['10.2337/figshare.12733202']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2217-2226Informations de copyright
© 2020 by the American Diabetes Association.
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