Mediator complex subunit Med19 binds directly GATA transcription factors and is required with Med1 for GATA-driven gene regulation
Activation domain
DNA-binding domain
Drosophila development
GATA transcription factor
GATA transcription factors
Med1
Med19
Pannier
Pnr
Serpent
Srp
cofactor
drosophila genetics
gene regulation
mediator complex
thoracic closure
transcription coregulator
transcription regulation
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
25 09 2020
25 09 2020
Historique:
received:
03
04
2020
revised:
21
07
2020
pubmed:
2
8
2020
medline:
7
2
2021
entrez:
2
8
2020
Statut:
ppublish
Résumé
The evolutionarily conserved multiprotein Mediator complex (MED) serves as an interface between DNA-bound transcription factors (TFs) and the RNA Pol II machinery. It has been proposed that each TF interacts with a dedicated MED subunit to induce specific transcriptional responses. But are these binary partnerships sufficient to mediate TF functions? We have previously established that the Med1 Mediator subunit serves as a cofactor of GATA TFs in
Identifiants
pubmed: 32737196
pii: S0021-9258(17)50017-4
doi: 10.1074/jbc.RA120.013728
pmc: PMC7521641
pii:
doi:
Substances chimiques
Drosophila Proteins
0
GATA Transcription Factors
0
Mediator Complex
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13617-13629Informations de copyright
© 2020 Immarigeon et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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