Characterization of pathological thyroid tissue using polarization-sensitive second harmonic generation microscopy.
Carcinoma, Papillary, Follicular
/ diagnostic imaging
Cell Differentiation
Collagen
/ chemistry
Diagnosis, Differential
Graves Disease
/ diagnostic imaging
Humans
Second Harmonic Generation Microscopy
/ instrumentation
Thyroid Cancer, Papillary
/ diagnostic imaging
Thyroid Diseases
/ diagnostic imaging
Thyroid Gland
/ diagnostic imaging
Thyroid Neoplasms
/ diagnostic imaging
Thyroid Nodule
/ diagnostic imaging
Journal
Laboratory investigation; a journal of technical methods and pathology
ISSN: 1530-0307
Titre abrégé: Lab Invest
Pays: United States
ID NLM: 0376617
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
01
06
2020
accepted:
09
07
2020
revised:
07
07
2020
pubmed:
2
8
2020
medline:
15
12
2020
entrez:
2
8
2020
Statut:
ppublish
Résumé
Polarization-sensitive second harmonic generation (SHG) microscopy is an established imaging technique able to provide information related to specific molecular structures including collagen. In this investigation, polarization-sensitive SHG microscopy was used to investigate changes in the collagen ultrastructure between histopathology slides of normal and diseased human thyroid tissues including follicular nodular disease, Grave's disease, follicular variant of papillary thyroid carcinoma, classical papillary thyroid carcinoma, insular or poorly differentiated carcinoma, and anaplastic or undifferentiated carcinoma ex vivo. The second-order nonlinear optical susceptibility tensor component ratios, χ
Identifiants
pubmed: 32737408
doi: 10.1038/s41374-020-0475-7
pii: S0023-6837(22)00350-6
doi:
Substances chimiques
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1280-1287Subventions
Organisme : CIHR
ID : CPG-134752
Pays : Canada
Organisme : CIHR
ID : CHRPJ 462842-14
Pays : Canada
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