Laryngopharyngeal reflux as a potential cause of persistent local neck symptoms after total thyroidectomy.


Journal

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
ISSN: 1434-4726
Titre abrégé: Eur Arch Otorhinolaryngol
Pays: Germany
ID NLM: 9002937

Informations de publication

Date de publication:
May 2021
Historique:
received: 04 05 2020
accepted: 16 07 2020
pubmed: 2 8 2020
medline: 24 4 2021
entrez: 2 8 2020
Statut: ppublish

Résumé

Local neck symptoms (LNS) may be related to goiter, but are also reported by patients suffering from laryngeal-pharyngeal reflux (LPR). The aim of this study was to investigate whether LPR could play a role in the persistence of some LNS after total thyroidectomy (TT). A consecutive case series of 160 patients with multinodular goiter (MNG) candidate for TT were included in this study. Each patient was closely studied for both the thyroid pathology and reflux disease before and 6 months after surgery to assess the persistence of LNS after surgery. Only throat discomfort showed a significant improvement (p  = 0.031) after surgery. On the other hand, swallowing and voice disorders persisted after surgery in 82.3% and 77.3% of patients, respectively (p  = 0.250 and p  = 0.062), such as the correlated reflux laryngopharyngitis (p  = 0.5). LPR can be considered a predisposing factor or an important concurrent causa to the persistence of LNS after TT, in particular for swallowing disorders and voice disorders. In patients with non-toxic MNG who complain of local neck symptoms, the investigation of a possible coexistence of a reflux disease is appropriate before surgery. Patients should be informed about the possibility that some symptoms can persist even after removal of the goiter.

Identifiants

pubmed: 32737644
doi: 10.1007/s00405-020-06223-0
pii: 10.1007/s00405-020-06223-0
pmc: PMC8057997
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1577-1583

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Références

Pinchera A, Aghini-Lombardi F, Antonangeli L, Vitti P (1996) Multinodular goiter. Epidemiology and prevention. Ann Ital Chir 67:317–325
pubmed: 9019982
Pereira JA, Girvent M, Sancho JJ, Parada C, Sitges-Sierra A (2003) Prevalence of long-term upper aero-digestive symptoms after uncomplicated bilateral thyroidectomy. Surgery 133:318–322
doi: 10.1067/msy.2003.58
Wong CKM, Wheeler MH (2000) Thyroid nodules: rational management. World J Surg 24:934–941
doi: 10.1007/s002680010175
Fiorentino E, Cipolla C, Graceffa G, CusimanoA Cupido F, Lo Re G, Matranga D, Latteri MA (2011) Local neck symptoms before and after thyroidectomy: a possible correlation with reflux laryngopharyngitis. Eur Arch Otorhinolaryngol 268:715–720
doi: 10.1007/s00405-010-1394-9
Lombardi CP, Raffaelli M, D’Alatri L, Marchese RM, Rigante M, Paludetti G, Bellantone R (2006) Voice and swallowing changes after thyroidectomy in patients without inferior laryngeal nerve injuries. Surgery 140:1026–1032
doi: 10.1016/j.surg.2006.08.008
Koufman JA (2002) Laryngopharyngeal reflux is different from classic gastroesophageal reflux disease. Ear Nose Throat J 81(9 Suppl 2):7–9
pubmed: 12353431
Reulbach TR, Belafsky PC, Blalock PD, Koufman JA, Postma GN (2001) Occult laryngeal pathology in a community-based cohort. Otolaryngol Head Neck Surg 124:448–450
doi: 10.1067/mhn.2001.114256
Belafsky PC, Postma GM, Admin MR, Koufman JA (2002) Symptoms and findings of laryngopharingeal reflux. Ear Nose Throat J 81(9 Suppl 2):10–13
pubmed: 12353425
Belafsky PC, Rees CJ (2008) Laryngopharyngeal reflux: the value of otolaryngology examination. Curr Gastroenterol Rep 10:278–282
doi: 10.1007/s11894-008-0056-1
Mesallam TA, Stemple JC, Sobeih TM, Elluru RG (2007) Reflux symptom index versus reflux finding score. Ann Otol Rhinol Laryngol 116:436–440
doi: 10.1177/000348940711600608
Lombardi CP, Raffaelli M, D’Alatri L, De Crea C, Marchese MR, Maccora D, Paludetti G, Bellantone R (2008) Video-assisted thyroidectomy significantly reduces the risk of early posttihyroidectomy voice and swallowing symptoms. World J Surg 32:693–700
doi: 10.1007/s00268-007-9443-2
Belafsky PC, Postma GN, Koufman JA (2001) The validity and reliability of the reflux finding score (RFS). Laryngoscope 111:1313–1317
doi: 10.1097/00005537-200108000-00001
Belafsky PC, Postma GN, Koufmann JA (2002) Validity and reliability of the reflux symptom index (RSI). J Voice 16:274–277
doi: 10.1016/S0892-1997(02)00097-8
Hamdan AL, Jabbour J, Al Zaghal Z, Azar ST (2012) Goiter and laryngopharyngeal reflux. ISRN Endocrinol 2012:208958
doi: 10.5402/2012/208958
Chen AY, Bernet VJ, Carty SE, Davies TF, Ganly I, Inabnet WB, Shaha AR (2014) American thyroid association statement on optimal surgical management of goiter. Thyroid 24:181–189
doi: 10.1089/thy.2013.0291
Cusimano A, Macaione I, Fiorentino E (2016) How uncomplicated total thyroidectomy could aggravate the laryngopharyngeal reflux disease? Eur Arch Otorhinolaryngol 273:197–202
doi: 10.1007/s00405-014-3474-8
Zawawi F, Richardson K, Varshney R, Young J, Mlymarek AM, Hier MP, Payne RJ (2013) Postthyroidectomy throat pain and swallowing: do proton pump inhibitors make a difference? ISRN Otorynolaryngol 2013:135978
WHO (1994) Indicators for assessing iodine deficiency disorders and their control through salt iodization. World Health Organization, Geneva, WHO/NUT/94.6. http://whqlibdoc.who.int/hq/1994/WHO_NUT_94.6.pdf . Accessed 4 May 2020

Auteurs

Calogero Cipolla (C)

Department of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro 129, 90127, Palermo, Italy.

Ina Macaione (I)

Department of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro 129, 90127, Palermo, Italy.

Salvatore Vieni (S)

Department of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro 129, 90127, Palermo, Italy.

Mario Latteri (M)

Department of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro 129, 90127, Palermo, Italy.

Angela Vullo (A)

Istituto Zooprofilattico Sperimentale della Sicilia, Via G. Marinuzzi 3, 90129, Palermo, Italy.

Giuseppa Graceffa (G)

Department of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro 129, 90127, Palermo, Italy.

Eugenio Fiorentino (E)

Department of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro 129, 90127, Palermo, Italy. eugenio.fiorentino@unipa.it.

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