Crossed Cerebellar Diaschisis in Patients with Diffuse Glioma Is Associated with Impaired Supratentorial Cerebrovascular Reactivity and Worse Clinical Outcome.
BOLD fMRI
Cerebrovascular reactivity
Crossed cerebellar diaschisis
Diffuse glioma
Supratentorial hemodynamic
Journal
Cerebellum (London, England)
ISSN: 1473-4230
Titre abrégé: Cerebellum
Pays: United States
ID NLM: 101089443
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
pubmed:
2
8
2020
medline:
20
8
2021
entrez:
2
8
2020
Statut:
ppublish
Résumé
Crossed cerebellar diaschisis (CCD) can be associated with impaired cerebrovascular reactivity (CVR) and poor clinical outcome, but whether this holds true for patients with diffuse glioma is unknown. With blood oxygenation level-dependent (BOLD)-CVR imaging, we determined the presence of CCD in patients with diffuse glioma and investigated its relationship with cerebrovascular reactivity and clinical outcome. For eighteen enrolled subjects (nineteen datasets) with diffuse glioma, CCD was deferred from BOLD-CVR using a predetermined cerebellar asymmetry index (CAI) cutoff value of 6.0%. A FET-PET study was done as a verification of the CCD diagnosis. BOLD-CVR values as well as clinical performance scores (i.e., Karnofsky performance score (KPS), disability rating scale (DRS), and modified Rankin scale (mRS)) by BOLD-CVR scan at 3-month clinical follow-up were assessed and compared for the CCD-positive and CCD-negative group. CCD was present in 26.3% of subjects and strongly associated with impaired BOLD-CVR of the affected (i.e., the hemisphere harboring the glioma) and unaffected supratentorial hemisphere (CCD(+) vs. CCD(-): 0.08 ± 0.11 vs. 0.18 ± 0.04; p = 0.007 and 0.08 ± 0.12 vs. 0.19 ± 0.04; p = 0.007, respectively). This finding was independent of tumor volume (p = 0.48). Furthermore, poorer initial (by scan) clinical performance scores at follow-up were found for the CCD(+) group. The presence of crossed cerebellar diaschisis in patients with diffuse glioma is associated with impaired supratentorial cerebrovascular reactivity and worse clinical outcome.
Identifiants
pubmed: 32737798
doi: 10.1007/s12311-020-01174-y
pii: 10.1007/s12311-020-01174-y
pmc: PMC7588366
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
824-832Subventions
Organisme : Swiss Cancer League
ID : KFS-3975-082016-R
Organisme : Swiss National Science Foundation
ID : PP00P3_170683
Pays : Switzerland
Références
Wiestler B, Kluge A, Lukas M, Gempt J, Ringel F, Schlegel J, et al. Multiparametric MRI-based differentiation of WHO grade II/III glioma and WHO grade IV glioblastoma. Sci Rep. 2016;6:35142. https://doi.org/10.1038/srep35142 .
doi: 10.1038/srep35142
pubmed: 27739434
pmcid: 5064384
Liu X, Li J, Xu Q, Mantini D, Wang P, Xie Y, et al. Pathological factors contributing to crossed cerebellar diaschisis in cerebral gliomas: a study combining perfusion, diffusion, and structural MR imaging. Neuroradiology. 2018;60:643–50. https://doi.org/10.1007/s00234-018-2015-3 .
doi: 10.1007/s00234-018-2015-3
pubmed: 29666881
Sebok M, van Niftrik CHB, Piccirelli M, Bozinov O, Wegener S, Esposito G, et al. BOLD cerebrovascular reactivity as a novel marker for crossed cerebellar diaschisis. Neurology. 2018. https://doi.org/10.1212/wnl.0000000000006287 .
Kunz WG, Sommer WH, Hohne C, Fabritius MP, Schuler F, Dorn F, et al. Crossed cerebellar diaschisis in acute ischemic stroke: impact on morphologic and functional outcome. J Cereb Blood Flow Metab. 2017;37:3615–24. https://doi.org/10.1177/0271678x16686594 .
doi: 10.1177/0271678x16686594
pubmed: 28084869
pmcid: 5669343
van Niftrik CHB, Piccirelli M, Bozinov O, Pangalu A, Fisher JA, Valavanis A, et al. Iterative analysis of cerebrovascular reactivity dynamic response by temporal decomposition. Brain Behav. 2017;7:e00705. https://doi.org/10.1002/brb3.705 .
doi: 10.1002/brb3.705
pubmed: 28948064
pmcid: 5607533
van Niftrik CHB, Piccirelli M, Bozinov O, Maldaner N, Strittmatter C, Pangalu A, et al. Impact of baseline CO2 on blood-oxygenation-level-dependent MRI measurements of cerebrovascular reactivity and task-evoked signal activation. Magn Reson Imaging. 2018a;49:123–30. https://doi.org/10.1016/j.mri.2018.02.002 .
doi: 10.1016/j.mri.2018.02.002
pubmed: 29447850
Fierstra J, van Niftrik B, Piccirelli M, Burkhardt JK, Pangalu A, Kocian R, et al. Altered intraoperative cerebrovascular reactivity in brain areas of high-grade glioma recurrence. Magn Reson Imaging. 2016;34:803–8. https://doi.org/10.1016/j.mri.2016.02.003 .
doi: 10.1016/j.mri.2016.02.003
pubmed: 26968146
Fierstra J, van Niftrik C, Piccirelli M, Bozinov O, Pangalu A, Krayenbuhl N, et al. Diffuse gliomas exhibit whole brain impaired cerebrovascular reactivity. Magn Reson Imaging. 2018;45:78–83. https://doi.org/10.1016/j.mri.2017.09.017 .
doi: 10.1016/j.mri.2017.09.017
pubmed: 28986176
Strother MK, Buckingham C, Faraco CC, Arteaga DF, Lu P, Xu Y, et al. Crossed cerebellar diaschisis after stroke identified noninvasively with cerebral blood flow-weighted arterial spin labeling MRI. Eur J Radiol. 2016;85:136–42. https://doi.org/10.1016/j.ejrad.2015.11.003 .
doi: 10.1016/j.ejrad.2015.11.003
pubmed: 26724658
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016, 131:803–20. https://doi.org/10.1007/s00401-016-1545-1 .
Wen PY, Macdonald DR, Reardon DA, Cloughesy TF, Sorensen AG, Galanis E, et al. Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group, J Clin Oncol. 2010;28:1963–72. https://doi.org/10.1200/jco.2009.26.3541 .
Slessarev M, Han J, Mardimae A, Prisman E, Preiss D, Volgyesi G, et al. Prospective targeting and control of end-tidal CO2 and O2 concentrations. J Physiol. 2007;581:1207–19. https://doi.org/10.1113/jphysiol.2007.129395 .
doi: 10.1113/jphysiol.2007.129395
pubmed: 17446225
pmcid: 2170842
van Niftrik CHB, Piccirelli M, Bozinov O, Maldaner N, Strittmatter C, Pangalu A, et al. Impact of baseline CO2 on blood-oxygenation-level-dependent MRI measurements of cerebrovascular reactivity and task-evoked signal activation. Magn Reson Imaging. 2018b. https://doi.org/10.1016/j.mri.2018.02.002 .
De Reuck J, Decoo D, Lemahieu I, Strijckmans K, Goethals P, Van Maele G. Crossed cerebellar diaschisis after middle cerebral artery infarction. Clin Neurol Neurosurg. 1997;99:11–6. https://doi.org/10.1016/s0303-8467(96)00561-6 .
doi: 10.1016/s0303-8467(96)00561-6
pubmed: 9107461
Baron JC, Bousser MG, Comar D, Castaigne P. “Crossed cerebellar diaschisis” in human supratentorial brain infarction. Trans Am Neurol Assoc. 1981;105:459–61.
pubmed: 19645126
Patronas NJ, Di Chiro G, Smith BH, De La Paz R, Brooks RA, Milam HL, et al. Depressed cerebellar glucose metabolism in supratentorial tumors. Brain Res. 1984;291:93–101. https://doi.org/10.1016/0006-8993(84)90654-1 .
doi: 10.1016/0006-8993(84)90654-1
pubmed: 6320957
Brooks DJ, Beaney RP, Lammertsma AA, Herold S, Turton DR, Luthra SK, et al. Glucose transport across the blood-brain barrier in normal human subjects and patients with cerebral tumours studied using [11C]3-O-methyl-D-glucose and positron emission tomography. J Cereb Blood Flow Metab. 1986;6:230–9. https://doi.org/10.1038/jcbfm.1986.36 .
doi: 10.1038/jcbfm.1986.36
pubmed: 3007547
Leenders KL, Beaney RP, Brooks DJ, Lammertsma AA, Heather JD, McKenzie CG. Dexamethasone treatment of brain tumor patients: effects on regional cerebral blood flow, blood volume, and oxygen utilization. Neurology. 1985;35:1610–6. https://doi.org/10.1212/wnl.35.11.1610 .
doi: 10.1212/wnl.35.11.1610
pubmed: 4058751
Venkatesh HS, Morishita W, Geraghty AC, Silverbush D, Gillespie SM, Arzt M, et al. Electrical and synaptic integration of glioma into neural circuits. Nature. 2019;573:539–45. https://doi.org/10.1038/s41586-019-1563-y .
doi: 10.1038/s41586-019-1563-y
pubmed: 31534222
pmcid: 7038898
Heeger DJ, Huk AC, Geisler WS, Albrecht DG. Spikes versus BOLD: what does neuroimaging tell us about neuronal activity? Nat Neurosci. 2000;3:631–3. https://doi.org/10.1038/76572 .
doi: 10.1038/76572
pubmed: 10862687
Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA. Glial and neuronal control of brain blood flow. Nature. 2010;468:232–43. https://doi.org/10.1038/nature09613 .
doi: 10.1038/nature09613
pubmed: 21068832
pmcid: 3206737
Hou BL, Bradbury M, Peck KK, Petrovich NM, Gutin PH, Holodny AI. Effect of brain tumor neovasculature defined by rCBV on BOLD fMRI activation volume in the primary motor cortex. NeuroImage. 2006;32:489–97. https://doi.org/10.1016/j.neuroimage.2006.04.188 .
doi: 10.1016/j.neuroimage.2006.04.188
pubmed: 16806983
Holodny AI, Schulder M, Liu WC, Maldjian JA, Kalnin AJ. Decreased BOLD functional MR activation of the motor and sensory cortices adjacent to a glioblastoma multiforme: implications for image-guided neurosurgery. AJNR Am J Neuroradiol. 1999;20:609–12.
pubmed: 10319970
pmcid: 7056038
Otte A, Roelcke U, von Ammon K, Hausmann O, Maguire RP, Missimer J, et al. Crossed cerebellar diaschisis and brain tumor biochemistry studied with positron emission tomography, [18F]fluorodeoxyglucose and [11C]methionine. J Neurol Sci. 1998;156:73–7. https://doi.org/10.1016/s0022-510x(98)00019-7 .
doi: 10.1016/s0022-510x(98)00019-7
pubmed: 9559990
Tien RD, Ashdown BC. Crossed cerebellar diaschisis and crossed cerebellar atrophy: correlation of MR findings, clinical symptoms, and supratentorial diseases in 26 patients. AJR Am J Roentgenol. 1992;158:1155–9. https://doi.org/10.2214/ajr.158.5.1566683 .
doi: 10.2214/ajr.158.5.1566683
pubmed: 1566683
Jussen D, Zdunczyk A, Schmidt S, Rosler J, Buchert R, Julkunen P, et al. Motor plasticity after extra-intracranial bypass surgery in occlusive cerebrovascular disease. Neurology. 2016;87:27–35. https://doi.org/10.1212/wnl.0000000000002802 .
doi: 10.1212/wnl.0000000000002802
pubmed: 27281529