Impact of surface functionalization on the toxicity and antimicrobial effects of selenium nanoparticles considering different routes of entry.
Anti-Infective Agents
/ pharmacology
Cell Line
Comet Assay
Endocytosis
/ drug effects
Escherichia coli
/ drug effects
Humans
Metal Nanoparticles
/ chemistry
Microbial Sensitivity Tests
Oxidative Stress
/ drug effects
Reactive Oxygen Species
/ metabolism
Saccharomyces cerevisiae
/ drug effects
Selenium
/ chemistry
Staphylococcus aureus
/ drug effects
Surface Properties
Antimicrobials
Food industry
Medical industry
Nanomaterials
Safety
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
27
02
2020
revised:
09
07
2020
accepted:
11
07
2020
pubmed:
2
8
2020
medline:
22
5
2021
entrez:
2
8
2020
Statut:
ppublish
Résumé
Selenium nanoparticles (SeNPs) were first designed as nutritional supplements, but they are attractive also for use in diagnostic and therapeutic systems owing to their biocompatibility and protective effects. This study aimed to examine if different SeNPs stabilization strategies affect their (i) antimicrobial activity against bacteria Escherichia coli and Staphylococcus aureus and yeast Saccharomyces cerevisiae and (ii) toxicity to human cells of different biological barriers i.e., skin, oral and intestinal mucosa. For surface stabilization, polyvinylpyrrolidone (PVP), poly-L-lysine (PLL) and polyacrylic acid (PAA) were used rendering neutral, positively and negatively charged SeNPs, respectively. The SeNPs (primary size ~80 nm) showed toxic effects in human cells in vitro and in bacteria S. aureus, but not in E. coli and yeast S. cerevisiae. Toxicity of SeNPs (24 h IC
Identifiants
pubmed: 32738372
pii: S0278-6915(20)30511-1
doi: 10.1016/j.fct.2020.111621
pii:
doi:
Substances chimiques
Anti-Infective Agents
0
Reactive Oxygen Species
0
Selenium
H6241UJ22B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111621Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.