Cortical plasticity in phantom limb pain: A fMRI study on the neural correlates of behavioral clinical manifestations.
Brain activation
Motor cortex
Motor cortex representation
Phantom limb pain
Somato-sensory cortex
Task-based fMRI
Visual cortex
Journal
Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001
Informations de publication
Date de publication:
30 10 2020
30 10 2020
Historique:
received:
28
12
2019
revised:
21
07
2020
accepted:
21
07
2020
pubmed:
2
8
2020
medline:
5
1
2021
entrez:
2
8
2020
Statut:
ppublish
Résumé
The neural mechanism of phantom limb pain (PLP) is related to the intense brain reorganization process implicating plasticity after deafferentation mostly in sensorimotor system. There is a limited understanding of the association between the sensorimotor system and PLP. We used a novel task-based functional magnetic resonance imaging (fMRI) approach to (1) assess neural activation within a-priori selected regions-of-interested (motor cortex [M1], somatosensory cortex [S1], and visual cortex [V1]), (2) quantify the cortical representation shift in the affected M1, and (3) correlate these changes with baseline clinical characteristics. In a sample of 18 participants, we found a significantly increased activity in M1 and S1 as well as a shift in motor cortex representation that was not related to PLP intensity. In an exploratory analyses (not corrected for multiple comparisons), they were directly correlated with time since amputation; and there was an association between increased activity in M1 with a lack of itching sensation and V1 activation was negatively correlated with PLP. Longer periods of amputation lead to compensatory changes in sensory-motor areas; and itching seems to be a protective marker for less signal changes. We confirmed that PLP intensity is not associated with signal changes in M1 and S1 but in V1.
Identifiants
pubmed: 32738724
pii: S0925-4927(20)30123-2
doi: 10.1016/j.pscychresns.2020.111151
pmc: PMC9394643
mid: NIHMS1618818
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
111151Subventions
Organisme : NICHD NIH HHS
ID : R01 HD082302
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors report no conflict of interest.
Références
Neuroimage. 2007 Jul 1;36(3):706-17
pubmed: 17524669
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12569-74
pubmed: 18723676
Brain. 2015 Aug;138(Pt 8):2140-6
pubmed: 26072517
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Neuroscience. 2018 Sep 1;387:85-91
pubmed: 29155276
Nature. 1996 Aug 29;382(6594):805-7
pubmed: 8752272
JMIR Res Protoc. 2016 Jul 06;5(3):e138
pubmed: 27383993
Pain. 2010 May;149(2):296-304
pubmed: 20359825
J Pain. 2008 May;9(5):417-22
pubmed: 18280211
J Neurosci. 2014 Mar 5;34(10):3622-31
pubmed: 24599461
Cereb Cortex. 2006 Feb;16(2):254-67
pubmed: 15888607
Clin Neurophysiol. 2020 Oct;131(10):2375-2382
pubmed: 32828040
Neuroimage. 2015 Jul 1;114:217-25
pubmed: 25776216
Cortex. 2017 Oct;95:29-36
pubmed: 28822914
Nat Neurosci. 2004 Feb;7(2):189-95
pubmed: 14730305
IEEE Trans Neural Syst Rehabil Eng. 2015 May;23(3):450-7
pubmed: 25051556
Neurosci Lett. 2012 Apr 11;514(1):127-30
pubmed: 22402190
Neuroimage Clin. 2015 Oct 03;9:599-606
pubmed: 26740913
Neuroreport. 2020 Jun 7;31(9):691-695
pubmed: 32427715
Sci Rep. 2015 May 21;5:10499
pubmed: 25994551
Psychol Res. 2019 Feb;83(1):196-204
pubmed: 30488117
J ECT. 2018 Sep;34(3):e36-e50
pubmed: 29952860
Neuroreport. 1998 Sep 14;9(13):3019-23
pubmed: 9804308
Brain. 2001 Nov;124(Pt 11):2268-77
pubmed: 11673327
Arch Phys Med Rehabil. 2011 Apr;92(4):653-6
pubmed: 21440712
Neuroimage. 2016 Apr 15;130:134-144
pubmed: 26854561
Pain. 2017 Apr;158(4):691-697
pubmed: 28030473
Neurology. 2006 Dec 26;67(12):2129-34
pubmed: 17082465
PLoS One. 2013 Aug 28;8(8):e72403
pubmed: 24015241
Arch Phys Med Rehabil. 2009 Apr;90(4):675-81
pubmed: 19345786
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Ann Rehabil Med. 2017 Aug;41(4):693-700
pubmed: 28971055
Neurosci Lett. 2019 Jan 18;690:89-94
pubmed: 30312754
Trends Cogn Sci. 2013 Jul;17(7):307-8
pubmed: 23608362
J Neurosci. 1997 Jul 15;17(14):5503-8
pubmed: 9204932
Cereb Cortex. 2006 Feb;16(2):268-79
pubmed: 15888606
Neuroimage. 2004;23 Suppl 1:S208-19
pubmed: 15501092
Neuroscience. 2001;102(2):263-72
pubmed: 11166112
J Neurol Neurosurg Psychiatry. 2011 Apr;82(4):393-8
pubmed: 20861065
Neuroimage. 2002 Oct;17(2):825-41
pubmed: 12377157
N Engl J Med. 2007 Nov 22;357(21):2206-7
pubmed: 18032777
Front Neurosci. 2020 Apr 21;14:314
pubmed: 32372907
Restor Neurol Neurosci. 2016 Sep 21;34(5):721-32
pubmed: 27232952
Hum Brain Mapp. 1996;4(1):58-73
pubmed: 20408186
Neuroreport. 1998 Apr 20;9(6):1013-7
pubmed: 9601659
J Pain. 2016 Feb;17(2):167-80
pubmed: 26552501
Int J Rehabil Res. 2011 Mar;34(1):1-13
pubmed: 21326041
Nat Commun. 2013;4:1570
pubmed: 23463013
Eur J Pain. 2014 May;18(5):729-39
pubmed: 24327313
J Vis Exp. 2019 Apr 20;(146):
pubmed: 31058883
Psychopharmacology (Berl). 2018 Nov;235(11):3273-3288
pubmed: 30310960
Nature. 1995 Jun 8;375(6531):482-4
pubmed: 7777055
Soc Cogn Affect Neurosci. 2007 Mar;2(1):67-70
pubmed: 18985121