Small molecule somatostatin receptor subtype 4 (sst

Amino Acid Sequence Analgesics / chemistry Animals Anti-Inflammatory Agents / chemistry CHO Cells Cricetinae Cricetulus Dose-Response Relationship, Drug Female HEK293 Cells Humans Male Pain Measurement / drug effects Protein Binding / physiology Protein Structure, Secondary Protein Structure, Tertiary Rats Rats, Wistar Receptors, Somatostatin / agonists
Analgesic drug Anti-inflammatory drug Inflammation Neuropathic pain Somatostatin Somatostatin receptor subtype 4

Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
01 11 2020
Historique:
received: 07 11 2019
revised: 07 06 2020
accepted: 10 06 2020
pubmed: 3 8 2020
medline: 13 8 2021
entrez: 3 8 2020
Statut: ppublish

Résumé

We provided strong proof of concept evidence that somatostatin mediates potent analgesic and anti-inflammatory actions via its receptor subtype 4 (sst

Identifiants

DOI: 10.1016/j.neuropharm.2020.108198 PMID: 32739276
pubmed: 32739276
pii: S0028-3908(20)30266-5
doi: 10.1016/j.neuropharm.2020.108198
pii:
doi:

Substances chimiques

Analgesics 0
Anti-Inflammatory Agents 0
Receptors, Somatostatin 0
somatostatin receptor subtype-4 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108198

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Éva Szőke (É)

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary; János Szentágothai Research Center & Centre for Neuroscience, University of Pécs, Hungary. Electronic address: eva.szoke@aok.pte.hu.

Mónika Bálint (M)

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary; János Szentágothai Research Center & Centre for Neuroscience, University of Pécs, Hungary.

Csaba Hetényi (C)

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary; János Szentágothai Research Center & Centre for Neuroscience, University of Pécs, Hungary.

Adrienn Markovics (A)

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary; János Szentágothai Research Center & Centre for Neuroscience, University of Pécs, Hungary.

Krisztián Elekes (K)

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary; János Szentágothai Research Center & Centre for Neuroscience, University of Pécs, Hungary.

Gábor Pozsgai (G)

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary; János Szentágothai Research Center & Centre for Neuroscience, University of Pécs, Hungary.

Tamás Szűts (T)

Biostatin Ltd, Budapest, Hungary.

György Kéri (G)

Vichem Chemie Research Ltd, Budapest, Hungary.

László Őrfi (L)

Department of Pharmaceutical Chemistry, Pharmacy Faculty, Semmelweis University, Budapest, Hungary.

Zoltán Sándor (Z)

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary; János Szentágothai Research Center & Centre for Neuroscience, University of Pécs, Hungary.

János Szolcsányi (J)

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary; János Szentágothai Research Center & Centre for Neuroscience, University of Pécs, Hungary.

Erika Pintér (E)

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary; János Szentágothai Research Center & Centre for Neuroscience, University of Pécs, Hungary; PharmInVivo Ltd, Pécs, Hungary; Algonist GmbH, Vienna, Austria.

Zsuzsanna Helyes (Z)

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary; János Szentágothai Research Center & Centre for Neuroscience, University of Pécs, Hungary; PharmInVivo Ltd, Pécs, Hungary; Algonist GmbH, Vienna, Austria.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Eucaryotes › Animaux › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules CHO › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Cricetulus › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Examen physique › Examen neurologique › Mesure de la douleur › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Small molecule somatostatin receptor subtype 4 (sst
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormones hypothalamiques hypophysotropes régulatrices › Récepteur somatostatine › Small molecule somatostatin receptor subtype 4 (sst