No evidence of sexual transmission of HEV among individuals using HIV pre-exposure prophylaxis.
HIV Pre-exposure prophylaxis
hepatitis E virus
incidence
men who have sex with men
seroprevalence
Journal
Journal of viral hepatitis
ISSN: 1365-2893
Titre abrégé: J Viral Hepat
Pays: England
ID NLM: 9435672
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
08
03
2020
revised:
10
06
2020
accepted:
19
07
2020
pubmed:
3
8
2020
medline:
1
9
2021
entrez:
3
8
2020
Statut:
ppublish
Résumé
We investigated the seroprevalence and incidence of hepatitis E virus (HEV) infection in men who have sex with men (MSM) who have been exposed to pre-exposure prophylaxis (PrEP) against HIV as sexual transmission of HEV has been suggested. A total of 147 PrEP-using MSM and 147 blood donors matched for sex, age and geographical area were tested for anti-HEV IgG and IgM. Among them, 135 have been followed for 1 year, at the end of which serological tests for HEV were performed retrospectively on stored samples. Laboratory data on sexual transmitted infections (STIs) and viral hepatitis, including hepatitis A virus (HAV), were collected. Baseline seroprevalence rates in PrEP users were 42.2% (anti-HEV IgG) and 3.4% (anti-HEV IgM). Those of the control blood donors were similar (anti-HEV IgG 43.5% and anti-HEV IgM 4.1%). There was no incident of HEV infection despite the rates of bacterial STIs (incidence rate (IR) = 46.6%) and HAV infection (IR = 15.8%). Age was the only risk factor associated with anti-HEV IgG seropositivity at baseline and at the end of follow-up. Sexual transmission does not seem to be a major route of HEV infection in MSM, unlike HAV.
Substances chimiques
Hepatitis Antibodies
0
Immunoglobulin M
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1495-1501Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
Kamar N, Izopet J, Pavio N, et al. Hepatitis E virus infection. Nat Rev Dis Primer. 2017;3:17086.
Doceul V, Bagdassarian E, Demange A, Pavio N. Zoonotic hepatitis E virus: classification, animal reservoirs and transmission routes. Viruses. 2016;8(10):270
Beebeejaun K, Degala S, Balogun K, et al. Outbreak of hepatitis A associated with men who have sex with men (MSM), England, July 2016 to January 2017. Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull. 2017;22(5):30454
Ndumbi P, Freidl GS, Williams CJ, et al. Hepatitis A outbreak disproportionately affecting men who have sex with men (MSM) in the European Union and European Economic Area, June 2016 to May 2017. Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull. 2018;23(33):1700641
Payne BAI, Medhi M, Ijaz S, et al. Hepatitis E virus seroprevalence among men who have sex with men, United Kingdom. Emerg Infect Dis. 2013;19(2):333-336.
Lanini S, Garbuglia AR, Lapa D, et al. Epidemiology of HEV in the Mediterranean basin: 10-year prevalence in Italy. BMJ Open. 2015;5(7):e007110.
Greco L, Uceda Renteria SC, Guarneri D, et al. HEV and HAV seroprevalence in men that have sex with men (MSM): An update from Milan, Italy. J Med Virol. 2018;90(8):1323-1327.
Dauby N, Suin V, Jacques M, et al. Hepatitis E virus (HEV): seroprevalence and HEV RNA detection in subjects attending a sexually transmitted infection clinic in Brussels, Belgium. Epidemiol Infect. 2017;145(16):3370-3374.
Heil J, Hoebe CJPA, van Loo IHM, Cals JWL, van Liere GAFS, Dukers-Muijrers NHTM. Hepatitis E prevalence in a sexual high-risk population compared to the general population. PLoS One. 2018;13(1):e0191798.
Alberts CJ, Schim van der Loeff MF, Sadik S, et al. Hepatitis E virus seroprevalence and determinants in various study populations in the Netherlands. PLoS One. 2018;13(12):e0208522.
Rodríguez-Tajes S, Perpiñán E, Leonel T, et al. Low seroprevalence and zero incidence rate of hepatitis E in men who have sex with men during a hepatitis A outbreak. J Med Virol. 2020;92(8):1359-1362.
Lin K-Y, Lin P-H, Sun H-Y, et al. Hepatitis E virus infections among HIV-positive individuals during an outbreak of acute hepatitis A in Taiwan. Hepatol Baltim Md. 2019;70(6):1892-1902.
Spada E, Costantino A, Pezzotti P, et al. Hepatitis E virus infection prevalence among men who have sex with men involved in a hepatitis A virus outbreak in Italy. Blood Transfus Trasfus Sangue. 2019;17(6):428-432.
Keane F, Gompels M, Bendall R, et al. Hepatitis E virus coinfection in patients with HIV infection. HIV Med. 2012;13(1):83-88.
Pineda JA, Cifuentes C, Parra M, et al. Incidence and natural history of hepatitis E virus coinfection among HIV-infected patients. AIDS Lond Engl. 2014;28(13):1931-1937.
Mansuy JM, Saune K, Rech H, et al. Seroprevalence in blood donors reveals widespread, multi-source exposure to hepatitis E virus, southern France, October 2011. Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull. 2015;20(19):27-34.
Mansuy JM, Gallian P, Dimeglio C, et al. A nationwide survey of hepatitis E viral infection in French blood donors. Hepatol Baltim Md. 2016;63(4):1145-1154.
Zhu F-C, Zhang J, Zhang X-F, et al. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet Lond Engl. 2010;376(9744):895-902.
Zhang J, Zhang X-F, Huang S-J, et al. Long-term efficacy of a hepatitis E vaccine. N Engl J Med. 2015;372(10):914-922.
Schemmerer M, Rauh C, Jilg W, Wenzel JJ. Time course of hepatitis E-specific antibodies in adults. J Viral Hepat. 2017;24(1):75-79.
Abravanel F, Lhomme S, Chapuy-Regaud S, et al. Hepatitis E virus reinfections in solid-organ-transplant recipients can evolve into chronic infections. J Infect Dis. 2014;209(12):1900-1906.
Legrand-Abravanel F, Mansuy J-M, Dubois M, et al. Hepatitis E Virus Genotype 3 Diversity. France. Emerg Infect Dis. 2009;15(1):110-114.
Smith DB, Simmonds P, Izopet J, et al. Proposed reference sequences for hepatitis E virus subtypes. J Gen Virol. 2016;97(3):537-542.
Chen G-J, Lin K-Y, Sun H-Y, et al. Incidence of acute hepatitis A among HIV-positive patients during an outbreak among MSM in Taiwan: Impact of HAV vaccination. Liver Int Off J Int Assoc Study Liver. 2018;38(4):594-601.
Wenzel JJ, Preiss J, Schemmerer M, Huber B, Jilg W. Test performance characteristics of Anti-HEV IgG assays strongly influence hepatitis E seroprevalence estimates. J Infect Dis. 2013;207(3):497-500.
Bendall R, Ellis V, Ijaz S, Ali R, Dalton H. A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries. J Med Virol. 2010;82(5):799-805.
Abravanel F, Chapuy-Regaud S, Lhomme S, et al. Performance of anti-HEV assays for diagnosing acute hepatitis E in immunocompromised patients. J Clin Virol Off Publ Pan Am Soc Clin Virol. 2013;58(4):624-628.
Kaba M, Richet H, Ravaux I, et al. Hepatitis E virus infection in patients infected with the human immunodeficiency virus. J Med Virol. 2011;83(10):1704-1716.
Jagjit Singh GK, Ijaz S, Rockwood N, et al. Chronic Hepatitis E as a cause for cryptogenic cirrhosis in HIV. J Infect. 2013;66(1):103-106.
Colson P, Kaba M, Moreau J, Brouqui P. Hepatitis E in an HIV-infected patient. J Clin Virol Off Publ Pan Am Soc Clin Virol. 2009;45(4):269-271.
Servant-Delmas A, Abravanel F, Lefrère J-J, et al. New insights into the natural history of hepatitis E virus infection through a longitudinal study of multitransfused immunocompetent patients in France. J Viral Hepat. 2016;23(7):569-575.
Charre C, Ramière C, Roque-Afonso A-M, et al. Hepatitis A outbreak in HIV-infected MSM and in PrEP-using MSM despite a high level of immunity, Lyon, France, January to June 2017. Euro Surveill Bull Eur Sur Mal Transm Eur Commun Dis Bull 2017;22(48):17-00742.
Delarocque-Astagneau E, Valenciano M, Dariosecq JM, et al. Une épidémie d’hépatite A chez des homosexuels masculins à Paris en 2000. Bulletin Epidémiologique Hebdomadaire. https://www.santepubliquefrance.fr/regions/ile-de-france/documents/article/2001/une-epidemie-d-hepatite-a-chez-des-homosexuels-masculins-a-paris-en-2000. Published 2001. Accessed January 5, 2020
Hogema BM, Molier M, Slot E, Zaaijer HL. Past and present of hepatitis E in the Netherlands. Transfusion (Paris). 2014;54(12):3092-3096.
Legrand-Abravanel F, Kamar N, Sandres-Saune K, et al. Hepatitis E virus infection without reactivation in solid-organ transplant recipients, France. Emerg Infect Dis. 2011;17(1):30-37.