Health-related quality of life after anonymous nondirected living liver donation: A multicenter collaboration.
clinical research/practice
donors and donation: living
liver transplantation/hepatology
liver transplantation: living donor
quality of life (QOL)
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
08
04
2020
revised:
14
07
2020
accepted:
14
07
2020
pubmed:
3
8
2020
medline:
22
6
2021
entrez:
3
8
2020
Statut:
ppublish
Résumé
Literature on living nondirected liver donation is sparse. The purpose of this study was to assess health-related quality of life (HR-QOL) in anonymous nondirected living liver donors (ND-LLDs). ND-LLDs at 3 centers: University of Alberta (n = 12), University of Colorado (n = 12), and University of Southern California (n = 12), were surveyed. Thirty donors (83%) responded to the Donor Quality of Life (USC DQLS) and Short-Form 36 (SF-36). Most respondents (n = 15, 50%) donated their left lateral segment, 27% right lobe, and 23% left lobe. The majority were female (67%) and mean age was 38.9 ± 11.2 years at donation. Median follow-up was 1.1 (interquartile range 0.4-3.3) years. Approximately 37% had previously donated a kidney. Eleven experienced ≥1 postoperative complication, with only 1 Clavien-Dindo IIIb. Most reported minimal impact on school or work performance, all felt positive or neutral about their overall health since donation, and none expressed postdonation regrets. No donor reported impacts on health insurability, and 3 of 4 respondents attempting to purchase life insurance postdonation were successful. ND-LLD SF-36 outcomes were similar to US population norms. Overall, ND-LLDs demonstrated acceptable HR-QOL after donation and are appropriate candidates for partial liver donation. Based on evaluation of donation impact, consideration should be given to postdonation support strategies.
Identifiants
pubmed: 32741102
doi: 10.1111/ajt.16229
pmc: PMC8351218
mid: NIHMS1729922
pii: S1600-6135(22)08441-6
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1056-1067Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR000130
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001855
Pays : United States
Organisme : National Center for Advancing Translational Science (NCATS)
ID : UL1TR000130
Organisme : National Center for Advancing Translational Science (NCATS)
ID : UL1TR001855
Informations de copyright
© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.
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