CD4
Adolescent
Adult
Aged
Aged, 80 and over
Antigens, Bacterial
/ immunology
Bacterial Proteins
/ immunology
CD4-Positive T-Lymphocytes
/ immunology
Case-Control Studies
Cell Proliferation
Cells, Cultured
Disease Progression
Female
Host-Pathogen Interactions
Humans
Interferon-gamma
/ metabolism
Interferon-gamma Release Tests
Latent Tuberculosis
/ immunology
Lymphocyte Activation
Male
Middle Aged
Models, Immunological
Mycobacterium tuberculosis
/ immunology
Predictive Value of Tests
Prospective Studies
Risk Assessment
Risk Factors
Tuberculin
/ immunology
Tuberculosis, Pulmonary
/ immunology
Young Adult
Cellular immunity
Diagnostics
Interferon-ɣ release assays
Tuberculosis
Journal
Tuberculosis (Edinburgh, Scotland)
ISSN: 1873-281X
Titre abrégé: Tuberculosis (Edinb)
Pays: Scotland
ID NLM: 100971555
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
22
08
2019
revised:
13
04
2020
accepted:
13
04
2020
entrez:
4
8
2020
pubmed:
4
8
2020
medline:
4
9
2021
Statut:
ppublish
Résumé
Interferon-γ release assays cannot differentiate latent from active tuberculosis (TB), nor identify the recently infected with increased risk of active disease. The objective of this study was to identify biomarkers of recent infection following exposure to tuberculosis, to increase the positive predictive value for incipient TB. Contacts to patients with pulmonary TB were tested repeatedly with interferon-γ release assays and flow-cytometry. Proliferative CD4
Identifiants
pubmed: 32741535
pii: S1472-9792(20)30126-8
doi: 10.1016/j.tube.2020.101959
pii:
doi:
Substances chimiques
Antigens, Bacterial
0
Bacterial Proteins
0
CFP-10 protein, Mycobacterium tuberculosis
0
ESAT-6 protein, Mycobacterium tuberculosis
0
IFNG protein, human
0
Tuberculin
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101959Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.