Assessment of Small Pulmonary Blood Vessels in COVID-19 Patients Using HRCT.
COVID-19
Pulmonary vascular disease
Quantitative CT metrics
Journal
Academic radiology
ISSN: 1878-4046
Titre abrégé: Acad Radiol
Pays: United States
ID NLM: 9440159
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
29
05
2020
revised:
16
07
2020
accepted:
17
07
2020
pubmed:
4
8
2020
medline:
9
10
2020
entrez:
4
8
2020
Statut:
ppublish
Résumé
Mounting evidence supports the role of pulmonary hemodynamic alternations in the pathogenesis of COVID-19. Previous studies have demonstrated that changes in pulmonary blood volumes measured on computed tomography (CT) are associated with histopathological markers of pulmonary vascular pruning, suggesting that quantitative CT analysis may eventually be useful in the assessment pulmonary vascular dysfunction more broadly. Building upon previous work, automated quantitative CT measures of small blood vessel volume and pulmonary vascular density were developed. Scans from 103 COVID-19 patients and 107 healthy volunteers were analyzed and their results compared, with comparisons made both on lobar and global levels. Compared to healthy volunteers, COVID-19 patients showed significant reduction in BV5 (pulmonary blood volume contained in blood vessels of <5 mm COVID-19 patients display striking anomalies in the distribution of blood volume within the pulmonary vascular tree, consistent with increased pulmonary vasculature resistance in the pulmonary vessels below the resolution of CT.
Identifiants
pubmed: 32741657
pii: S1076-6332(20)30442-6
doi: 10.1016/j.acra.2020.07.019
pmc: PMC7381940
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1449-1455Informations de copyright
Copyright © 2020 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.
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