Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats.
aging
behavior
electrical stimulation
neurogenesis
rats
stroke
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
04
2020
accepted:
19
06
2020
entrez:
4
8
2020
pubmed:
4
8
2020
medline:
4
8
2020
Statut:
epublish
Résumé
The major aim of stroke therapies is to stimulate brain repair and to improve behavioral recuperation after cerebral ischemia. Despite remarkable advances in cell therapy for stroke, stem cell-based tissue replacement has not been achieved yet stimulating the search for alternative strategies for brain self-repair using the neurogenic zones of the brain, the dentate gyrus and the subventricular zone (SVZ). However, during aging, the potential of the hippocampus and the SVZ to generate new neuronal precursors, declines. We hypothesized that electrically stimulation of endogenous neurogenesis in aged rats could increase the odds of brain self-repair and improve behavioral recuperation after focal ischemia. Following stroke in aged animals, the rats were subjected to two sessions of electrical non-convulsive stimulation using ear-clip electrodes, at 7- and 24 days after MCAO. Animal were sacrificed after 48 days. We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze) but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the gene that were unique to ES, we noted increases in the expression of
Identifiants
pubmed: 32742258
doi: 10.3389/fnins.2020.00732
pmc: PMC7365235
doi:
Types de publication
Journal Article
Langues
eng
Pagination
732Informations de copyright
Copyright © 2020 Balseanu, Grigore, Pinosanu, Slevin, Hermann, Glavan and Popa-Wagner.
Références
J Neurosci. 2006 Jun 14;26(24):6627-36
pubmed: 16775151
J Immunol. 2014 Oct 1;193(7):3248-55
pubmed: 25240020
Chin Med J (Engl). 2013 Jun;126(12):2361-7
pubmed: 23786955
Biomed Res Int. 2015;2015:736104
pubmed: 26417600
Immunogenetics. 2018 Jan;70(1):67-72
pubmed: 28936707
Arch Gen Psychiatry. 2000 May;57(5):425-34
pubmed: 10807482
Neurobiol Stress. 2018 May 19;9:9-21
pubmed: 29992181
Neuroimage. 2013 Jun;73:239-54
pubmed: 22846632
J Cereb Blood Flow Metab. 2012 Aug;32(8):1632-42
pubmed: 22617647
Molecules. 2017 Apr 23;22(4):
pubmed: 28441750
Exp Neurol. 2016 May;279:127-136
pubmed: 26923911
J Cell Physiol. 2017 Mar;232(3):665-677
pubmed: 27699791
Acta Neuropathol. 2007 Mar;113(3):277-93
pubmed: 17131130
Biol Psychiatry. 1983 Nov;18(11):1301-10
pubmed: 6317065
Physiol Behav. 2016 Sep 1;163:107-114
pubmed: 27143252
J Comp Neurol. 2011 Apr 15;519(6):1165-80
pubmed: 21344407
Exp Neurol. 2010 Apr;222(2):211-8
pubmed: 20059998
J Neurosci. 1997 May 15;17(10):3727-38
pubmed: 9133393
Mol Neurodegener. 2016 Oct 5;11(1):67
pubmed: 27716410
Metab Brain Dis. 2019 Oct;34(5):1261-1266
pubmed: 31123898
Nature. 2019 Jan;565(7737):86-90
pubmed: 30532001
Biol Psychiatry. 2000 Jun 15;47(12):1043-9
pubmed: 10862803
Physiol Behav. 2020 Feb 1;214:112769
pubmed: 31816276
J Comp Neurol. 2006 Jan 20;494(3):415-34
pubmed: 16320258
Neurobiol Dis. 2017 Mar;99:47-57
pubmed: 28007584
Brain Behav. 2018 Oct;8(10):e01062
pubmed: 30244532
N Engl J Med. 2007 Nov 8;357(19):1939-45
pubmed: 17989386
Exp Neurol. 2010 Mar;222(1):135-43
pubmed: 20045410
Mol Psychiatry. 2018 Jun;23(6):1496-1505
pubmed: 28485403
Brain Res. 2011 Jan 7;1367:77-84
pubmed: 20934411
Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7993-8
pubmed: 20385829
PLoS One. 2012;7(6):e39302
pubmed: 22768071
PLoS One. 2013 Jul 26;8(7):e69869
pubmed: 23922833
J Neurosci. 2009 Apr 22;29(16):5075-87
pubmed: 19386903
Behav Brain Res. 2012 Feb 14;227(2):400-9
pubmed: 21821065
Stroke. 2010 Sep;41(9):e552-60
pubmed: 20671247
Behav Brain Res. 2020 Apr 6;383:112512
pubmed: 31991177
Front Cell Neurosci. 2015 Sep 24;9:365
pubmed: 26441536
Stem Cells Int. 2016;2016:2715196
pubmed: 27403166
Brain Stimul. 2008 Apr;1(2):71-83
pubmed: 19756236
Elife. 2015 Mar 13;4:
pubmed: 25768425
Neurology. 2002 Mar 12;58(5):709-16
pubmed: 11889232
Kaohsiung J Med Sci. 2020 Jun;36(6):405-416
pubmed: 32003536
Exp Clin Endocrinol Diabetes. 2015 Sep;123(8):461-5
pubmed: 26069074
Eur J Neurosci. 1998 Dec;10(12):3853-68
pubmed: 9875362
Neuroscience. 2001;105(1):33-41
pubmed: 11483298
Glia. 2014 May;62(5):790-803
pubmed: 24677590
Front Cell Neurosci. 2016 Aug 08;10:188
pubmed: 27551261
Front Aging Neurosci. 2014 Mar 18;6:44
pubmed: 24672479
Neural Regen Res. 2015 Sep;10(9):1349-55
pubmed: 26604877
J ECT. 2010 Sep;26(3):159-74
pubmed: 20805726
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E168-77
pubmed: 24351932
Biomarkers. 2018 May - Jun;23(4):392-405
pubmed: 29385837
Stroke. 2010 May;41(5):1027-31
pubmed: 20360546
Cell. 2015 Jun 18;161(7):1644-55
pubmed: 26091041
Ann Neurol. 2002 Dec;52(6):802-13
pubmed: 12447935
Restor Neurol Neurosci. 2007;25(5-6):467-84
pubmed: 18334765
Nat Med. 2002 Sep;8(9):963-70
pubmed: 12161747
J Immunol. 2014 Sep 15;193(6):2881-90
pubmed: 25127855
Eur J Pharm Sci. 2017 May 30;103:47-51
pubmed: 28188910
J Cereb Blood Flow Metab. 2003 Jul;23(7):845-54
pubmed: 12843788
Front Aging Neurosci. 2014 Jun 23;6:130
pubmed: 25002846
Autophagy. 2016 Jul 2;12(7):1168-79
pubmed: 27171858