Hydralazine-Induced Dual Antineutrophil Cytoplasmic Antibody Positive Vasculitis and Nephritis.

acute kidney injury (aki) antineutrophil cytoplasmic antibody (anca) antineutrophil cytoplasmic antibody (anca) associated vasculitis (aav) drug-induced lupus (dil) dual anca aav and dil hydralazine hydralazine induced dual aav and dil pauci-immune glomerulonephritis (gn)

Journal

Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737

Informations de publication

Date de publication:
29 Jun 2020
Historique:
entrez: 4 8 2020
pubmed: 4 8 2020
medline: 4 8 2020
Statut: epublish

Résumé

Drug-induced autoimmunity occurs when exposure to a causative agent leads to serologic or clinical autoimmune responses. Syndromes that may be associated with drug-induced autoimmunity include antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) and drug-induced lupus (DIL). When drug-induced autoimmunity involves the kidney, histological patterns of injury include pauci-immune glomerulonephritis (GN), which occurs with AAV, and immune complex-mediated GN, which is associated with DIL. We present a case of hydralazine-induced dual ANCA-positive vasculitis and nephritis.

Identifiants

pubmed: 32742877
doi: 10.7759/cureus.8911
pmc: PMC7389885
doi:

Types de publication

Case Reports

Langues

eng

Pagination

e8911

Informations de copyright

Copyright © 2020, Padala et al.

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

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Auteurs

Sandeep A Padala (SA)

Nephrology, Augusta University Medical College of Georgia, Augusta, USA.

Vidya M Medepalli (VM)

Medicine, Augusta University Medical College of Georgia, Augusta, USA.

Azeem Mohammed (A)

Nephrology, Augusta University Medical College of Georgia, Augusta, USA.

Stanley Nahman (S)

Nephrology, Augusta University Medical College of Georgia, Augusta, USA.

Classifications MeSH