Expression of PD-L1 and CTLA-4 in female urethral carcinoma.
CTLA‐4
PD‐L1
female urethral cancer
immunocheckpoint inhibitor
Journal
IJU case reports
ISSN: 2577-171X
Titre abrégé: IJU Case Rep
Pays: Australia
ID NLM: 101764958
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
06
08
2018
accepted:
03
11
2018
entrez:
4
8
2020
pubmed:
23
11
2018
medline:
23
11
2018
Statut:
epublish
Résumé
Although the tumors are often easily detected, a considerable number of patients with female urethral carcinoma are diagnosed in an advance stage. Thus, no evidence-based therapeutic approach has been established. We herein report our experience in the treatment of three female patients with urethral carcinoma. We also examined the expression of PD-L1 and CTLA-4. Three female patients pathologically diagnosed with urethral carcinoma, including urothelial carcinoma, squamous cell carcinoma, and adenocarcinoma, between 2013 and 2017 were analyzed in this study. Two patients underwent urethrectomy with cystostomy. Immunohistochemistry was performed to assess the levels of PD-L1 and CTLA-4 expression in patients with urethral carcinoma. Eleven control cases of urethral carcinoma tissue were also stained. This study revealed the expression of PD-L1 and CTLA-4 in female urethral carcinomas.
Identifiants
pubmed: 32743365
doi: 10.1002/iju5.12029
pii: IJU512029
pmc: PMC7292119
doi:
Types de publication
Case Reports
Langues
eng
Pagination
23-26Informations de copyright
© 2018 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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