Neoadjuvant chemotherapy for high-risk prostatic adenocarcinoma.
docetaxel
neoadjuvant chemotherapy
prostate cancer
prostatectomy
prostatic adenocarcinoma
Journal
IJU case reports
ISSN: 2577-171X
Titre abrégé: IJU Case Rep
Pays: Australia
ID NLM: 101764958
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
31
07
2018
accepted:
03
11
2018
entrez:
4
8
2020
pubmed:
28
1
2019
medline:
28
1
2019
Statut:
epublish
Résumé
Neoadjuvant chemotherapy in high-risk, locally advanced prostate cancer remains an understudied area of prostate cancer. Chemotherapy continues to be a viable option. The combination with surgery may be desired but lacks data for complete recommendation. We demonstrate the successful utilization of chemotherapy in the neoadjuvant arena. A 70-year-old male was diagnosed with high-risk prostate cancer on biopsy. Upon multiparametric magnetic resonance imaging, the patient had local rectal wall invasion and stage T4 N0 M0 after a negative bone scan. After treatment with androgen-deprivation therapy and docetaxel, repeat multiparametric magnetic resonance imaging showed regression of rectal invasion. The patient elected for prostatectomy and avoided proctectomy and colostomy. The patient's postoperative prostate-specific antigen was undetectable on initial follow-up. We show that neoadjuvant chemotherapy merits further study and may provide a more permanent surgical option for patients.
Identifiants
pubmed: 32743374
doi: 10.1002/iju5.12031
pii: IJU512031
pmc: PMC7292178
doi:
Types de publication
Case Reports
Langues
eng
Pagination
61-64Informations de copyright
© 2019 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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