Changing the enzalutamide form from a capsule to a tablet improves the adherence of medicine intake: A case of a significant decrease in the prostate-specific antigen level and improvement in radiographic findings.
dosage form
enzalutamide
enzalutamide capsule
enzalutamide tablet
Journal
IJU case reports
ISSN: 2577-171X
Titre abrégé: IJU Case Rep
Pays: Australia
ID NLM: 101764958
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
28
11
2018
accepted:
02
03
2019
entrez:
4
8
2020
pubmed:
18
3
2019
medline:
18
3
2019
Statut:
epublish
Résumé
In June 2018, enzalutamide began to be sold in a tablet form in Japan and Germany. We herein report the case of an improvement in prostate cancer progression due to changing enzalutamide dosage form from a capsule to a tablet. A 76-year-old man was initially referred to our hospital for the further examination of his elevated prostate-specific antigen level (3664.0 ng/mL). He had developed castration-resistant prostate cancer 10 months after initial treatment. Treatment with enzalutamide (capsule form) was subsequently initiated. In June 2018, drug form of enzalutamide was changed from a capsule to a tablet. After switching to an enzalutamide tablet, his prostate-specific antigen level decreased significantly from 493.0 to 26.5 ng/mL. While the reason for this prostate-specific antigen response is unclear, changing the enzalutamide form from a capsule to a tablet may have improved the adherence of drug intake and thereby resulted in castration-resistant prostate cancer control.
Identifiants
pubmed: 32743396
doi: 10.1002/iju5.12062
pii: IJU512062
pmc: PMC7292163
doi:
Types de publication
Case Reports
Langues
eng
Pagination
143-145Informations de copyright
© 2019 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Smooth Muscle Res. 1996 Apr;32(2):43-50
pubmed: 8845565
N Engl J Med. 2014 Jul 31;371(5):424-33
pubmed: 24881730
Crit Care Nurs Clin North Am. 1996 Mar;8(1):79-89
pubmed: 8695038
Br Med J (Clin Res Ed). 1982 Dec 11;285(6356):1717-9
pubmed: 6816343
Biol Pharm Bull. 2011;34(11):1765-8
pubmed: 22040893
J Pharm Sci. 1982 Sep;71(9):975-7
pubmed: 7131280
Spec Care Dentist. 1996 May-Jun;16(3):95-103
pubmed: 9084322
N Engl J Med. 2012 Sep 27;367(13):1187-97
pubmed: 22894553