A patient with primary biliary cholangitis, autoimmune hepatitis, and primary sclerosing cholangitis variant syndrome.
Autoimmune hepatitis
Normal serum alkaline phosphatase level
Primary biliary cholangitis
Primary sclerosing cholangitis
Variant syndrome
Journal
Journal of translational autoimmunity
ISSN: 2589-9090
Titre abrégé: J Transl Autoimmun
Pays: Netherlands
ID NLM: 101759413
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
12
2019
accepted:
13
12
2019
entrez:
4
8
2020
pubmed:
4
8
2020
medline:
4
8
2020
Statut:
epublish
Résumé
Overlap between autoimmune hepatitis (AIH) and either primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC) is not rare and has extensively been reported. We herein report the first well documented case of triple overlap. A 68-year-old male patient presented with asymptomatic PBC including normal alkaline phosphatase serum level, developed AIH five years later, associated with magnetic resonance cholangiopancreatography biliary changes typical for PSC. Despite treatment with ursodeoxycholic acid and mycophenolate mofetil, owing to prednisone and azathioprine intolerance, he continued to have interface hepatitis and developed increasing fibrosis at follow-up liver biopsy. Our case report raises awareness for this rare and difficult to diagnose and treat clinical phenotype.
Identifiants
pubmed: 32743518
doi: 10.1016/j.jtauto.2019.100033
pii: S2589-9090(19)30033-4
pii: 100033
pmc: PMC7388380
doi:
Types de publication
Case Reports
Langues
eng
Pagination
100033Informations de copyright
© 2019 The Authors.
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