MicroRNAs in ankylosing spondylitis: Function, potential and challenges.
Journal
Journal of translational autoimmunity
ISSN: 2589-9090
Titre abrégé: J Transl Autoimmun
Pays: Netherlands
ID NLM: 101759413
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
03
2020
accepted:
16
03
2020
entrez:
4
8
2020
pubmed:
4
8
2020
medline:
4
8
2020
Statut:
epublish
Résumé
Epigenetic mechanisms such as DNA methylation, histone modifications and non-coding RNA, are considered the essential connection between a disorder's onset and the environment, on a permissive genetic background. Among autoimmune and inflammatory-mediated disorders, Ankylosing Spondylitis (AS), a chronic arthritis of the spine, is a very good example for the weight of epigenetics' contribution. MicroRNAs (miRNAs) are single-stranded nucleotides which regulate gene expression and are involved in pathological and physiological processes. In this manuscript we provide a clarification on the role of microRNAs in AS, with a focus on the mechanisms of pathogenesis. In specific, we have examined the contribution of miRNAs in the processes of inflammation, new bone formation and T-cell function, and the pathways (i.e. Wnt, BMP, TGFβ signalling etc.) they regulate. The utility of miRNAs in better understanding AS pathogenesis is undisputed and their utility as therapeutic opportunity is strongly increasing.
Identifiants
pubmed: 32743531
doi: 10.1016/j.jtauto.2020.100050
pii: S2589-9090(20)30017-4
pii: 100050
pmc: PMC7388379
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100050Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Ann Rheum Dis. 2016 Dec;75(12):2150-2156
pubmed: 26916345
Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6056-6066
pubmed: 32123118
Cell. 1993 Dec 3;75(5):843-54
pubmed: 8252621
Ann Rheum Dis. 2009 Jun;68(6):777-83
pubmed: 19297344
Annu Rev Immunol. 2015;33:29-48
pubmed: 25861975
Bone Res. 2019 Aug 5;7:22
pubmed: 31666997
Biosci Trends. 2011;5(2):46-51
pubmed: 21572246
Mediators Inflamm. 2016;2016:9607946
pubmed: 27594771
Wound Repair Regen. 2018 Jul;26(4):311-323
pubmed: 30118158
PLoS One. 2015 Sep 14;10(9):e0137770
pubmed: 26366721
Nat Rev Rheumatol. 2016 Feb;12(2):81-91
pubmed: 26439405
Oncotarget. 2017 Nov 27;8(69):113543-113557
pubmed: 29371928
Ann Rheum Dis. 2017 Jun;76(6):978-991
pubmed: 28087505
J Autoimmun. 2009 May-Jun;32(3-4):189-94
pubmed: 19303254
J Autoimmun. 2019 Aug;102:126-132
pubmed: 31128893
Clin Cancer Res. 2009 Sep 1;15(17):5473-7
pubmed: 19706812
Adv Clin Exp Med. 2019 Oct;28(10):1293-1300
pubmed: 31538414
Nat Rev Rheumatol. 2010 Jul;6(7):391-8
pubmed: 20517293
Nat Rev Mol Cell Biol. 2019 Jan;20(1):5-20
pubmed: 30228348
Mod Rheumatol. 2015 Sep;25(5):784-9
pubmed: 25736362
Science. 2001 Aug 10;293(5532):1074-80
pubmed: 11498575
Nat Genet. 2011 Jul 10;43(8):761-7
pubmed: 21743469
Clin Rheumatol. 2019 May;38(5):1367-1373
pubmed: 30911942
Front Immunol. 2019 Jan 10;9:3132
pubmed: 30687330
Arthritis Rheumatol. 2014 Feb;66(2):284-94
pubmed: 24504800
J Rheumatol. 2014 Jun;41(6):1104-11
pubmed: 24786924
Arthritis Rheumatol. 2018 Jul;70(7):1056-1070
pubmed: 29481736
Mod Rheumatol. 2014 Mar;24(2):331-4
pubmed: 24593209
Nat Genet. 2007 Nov;39(11):1329-37
pubmed: 17952073
J Cell Biochem. 2019 Sep;120(9):15429-15442
pubmed: 31111563
Nat Rev Rheumatol. 2018 May;14(5):249
pubmed: 29563554
Nature. 2008 Oct 23;455(7216):1124-8
pubmed: 18806776
Rheumatology (Oxford). 2019 Mar 1;58(3):388-400
pubmed: 29860356
Int J Mol Sci. 2019 Oct 17;20(20):
pubmed: 31627424
N Engl J Med. 1999 Oct 21;341(17):1284-91
pubmed: 10528040
Lancet. 2017 Jul 1;390(10089):73-84
pubmed: 28110981
Clin Lab. 2017 May 1;63(5):955-960
pubmed: 28627829
Cell. 1993 Dec 3;75(5):855-62
pubmed: 8252622
Arthritis Res Ther. 2017 Jul 25;19(1):177
pubmed: 28743287
Nat Genet. 2013 Jul;45(7):730-8
pubmed: 23749187
N Engl J Med. 2016 Jun 30;374(26):2563-74
pubmed: 27355535
Lancet. 1973 Apr 28;1(7809):904-7
pubmed: 4123836
Curr Opin Mol Ther. 2009 Apr;11(2):189-99
pubmed: 19330724
Biochem Biophys Res Commun. 2014 Oct 31;453(4):728-34
pubmed: 25305490
Expert Opin Ther Targets. 2016 Jun;20(6):737-53
pubmed: 26652031
Nat Rev Immunol. 2010 Feb;10(2):111-22
pubmed: 20098459
Hum Genet. 2013 Dec;132(12):1395-404
pubmed: 23928854
Joint Bone Spine. 2014 Dec;81(6):544-5
pubmed: 24703624
Clin Rev Allergy Immunol. 2018 Dec;55(3):332-339
pubmed: 28779298
Cancer Lett. 2018 Aug 1;428:90-103
pubmed: 29680223
Arthritis Res Ther. 2013 Apr 03;15(2):209
pubmed: 23566317
Arthritis Res Ther. 2008;10(5):R104
pubmed: 18761747
Rheumatol Int. 2015 Jun;35(6):973-9
pubmed: 25432079
Nat Rev Rheumatol. 2017 Jun;13(6):359-367
pubmed: 28446810
N Engl J Med. 2013 May 2;368(18):1685-94
pubmed: 23534542
Cell. 2004 Jan 23;116(2):281-97
pubmed: 14744438
Clin Exp Immunol. 2013 Jul;173(1):47-57
pubmed: 23607629
Nature. 2012 Sep 6;489(7414):109-13
pubmed: 22955621
Ann Rheum Dis. 2017 Mar;76(3):620-625
pubmed: 28039186
Rheumatology (Oxford). 2018 Aug 1;57(suppl_6):vi4-vi9
pubmed: 30445483
Cell. 2006 Sep 22;126(6):1203-17
pubmed: 16990141
Nat Genet. 2016 May;48(5):510-8
pubmed: 26974007