No evidence of autoimmunity to human OX

Autoimmunity Influenza A virus nucleoprotein Narcolepsy OX1 OX2 Pandemrix vaccination

Journal

Journal of translational autoimmunity
ISSN: 2589-9090
Titre abrégé: J Transl Autoimmun
Pays: Netherlands
ID NLM: 101759413

Informations de publication

Date de publication:
2020
Historique:
received: 12 08 2019
revised: 15 04 2020
accepted: 23 04 2020
entrez: 4 8 2020
pubmed: 4 8 2020
medline: 4 8 2020
Statut: epublish

Résumé

Narcolepsy type 1, likely an immune-mediated disease, is characterized by excessive daytime sleepiness and cataplexy. The disease is strongly associated with human leukocyte antigen (HLA) DQB1∗06:02. A significant increase in the incidence of childhood and adolescent narcolepsy was observed after a vaccination campaign with AS03-adjuvanted Pandemrix influenza vaccine in Nordic and several other countries in 2010 and 2011. Previously, it has been suggested that a surface-exposed region of influenza A nucleoprotein, a structural component of the Pandemrix vaccine, shares amino acid residues with the first extracellular domain of the human OX

Identifiants

pubmed: 32743535
doi: 10.1016/j.jtauto.2020.100055
pii: S2589-9090(20)30022-8
pii: 100055
pmc: PMC7388359
doi:

Types de publication

Journal Article

Langues

eng

Pagination

100055

Informations de copyright

© 2020 The Authors.

Déclaration de conflit d'intérêts

The authors declare that they have no competing interests.

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Auteurs

Krister Melén (K)

Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.
Expert Microbiology Unit, Finnish Institute for Health and Welfare, Mannerheimintie 166, 00300, Helsinki, Finland.

Pinja Jalkanen (P)

Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.

Jyrki P Kukkonen (JP)

Department of Physiology and Department of Pharmacology, Institute of Biomedicine, Faculty of Medicine and Biochemistry and Cell Biology, Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.

Markku Partinen (M)

Helsinki Sleep Clinic, Vitalmed Research Centre Helsinki and Medicum, Faculty of Medicine, University of Helsinki, Finland.

Hanna Nohynek (H)

Infectious Disease Control and Vaccination Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.

Arja Vuorela (A)

Reseach Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki.

Outi Vaarala (O)

Reseach Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki.

Tobias L Freitag (TL)

Department of Bacteriology and Immunology and Translational Immunology Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Seppo Meri (S)

Department of Bacteriology and Immunology and Translational Immunology Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Ilkka Julkunen (I)

Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland.
Turku University Hospital, Clinical Microbiology, Kiinamyllynkatu 10, 20520, Turku, Finland.

Classifications MeSH