Aspartic acid
Autoimmune thyroid disease
Graves’ disease
HLA-DRB1
Hashimoto’s disease
Multiple autoimmunities
Rheumatoid arthritis
Shared epitope
Journal
Journal of translational autoimmunity
ISSN: 2589-9090
Titre abrégé: J Transl Autoimmun
Pays: Netherlands
ID NLM: 101759413
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
04
2020
accepted:
04
05
2020
entrez:
4
8
2020
pubmed:
4
8
2020
medline:
4
8
2020
Statut:
epublish
Résumé
Autoimmune thyroid disease (AITD) is the most common autoimmune disorder worldwide. Remarkably, it is commonly accompanied by other autoimmune diseases, such as rheumatoid arthritis (RA). The immunopathogenic mechanisms behind the coexistence of these disorders are still not completely understood. Immunogenetics influences the physiopathology of these diseases since ethnicity plays an essential role in the inheritance of susceptibility markers. High-resolution HLA class II typing was performed using a sequence-based method. The allele frequency of HLA-DRB1∗04:04 and -DRB1∗03:01 were significantly increased in patients with AITD and RA compared to healthy individuals, pC = 0.021, OR = 2.4, 95%CI = 1.19-4.75 and pC = 0.009, OR = 3.4, 95%CI = 1.42-7.93, respectively. Remarkably, these patients have a combined risk given by susceptibility HLA-DRB1 alleles that contain the shared epitope, pC = 0.03, OR = 1.7, IC95% = 1.07-2.76, and a lack of protective alleles carrying aspartic acid The results suggest that patients with AITD and RA have an immunogenetic mechanism that combines the susceptibility alleles associated with both diseases. Importantly, it seems to be linked mainly to the lack of protective alleles with aspartic acid in the position 70, along with the presence of susceptibility alleles that have the sequences QRRAA, QKRAA, and RRRAA at positions 70-74. Patients with AITD and RA have a characteristic immunogenetic signature, which could be useful for determining multiple autoimmunities and assessing their relatives' risk of developing it.
Identifiants
pubmed: 32743537
doi: 10.1016/j.jtauto.2020.100057
pii: S2589-9090(20)30024-1
pii: 100057
pmc: PMC7388401
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100057Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
The author(s) declared no potential conflicts of interest concerning the research, authorship, and publication of this article.
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